The clinical efficacy and safety of equipment-assisted intravesical instillation of mitomycin C after transurethral resection of bladder tumour in patients with nonmuscular invasive bladder cancer: A meta-analysis

Background This review and meta-analysis aimed to systematically evaluate the clinical efficacy and safety of equipment-assisted intravesical instillation of mitomycin C (MMC) in patients with nonmuscular invasive bladder cancer (NMIBC) after transurethral resection of bladder tumour (TURBT). Method...

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Bibliographic Details
Published in:PloS one 2022-10, Vol.17 (10), p.e0276453-e0276453
Main Authors: Zhou, Weijian, Liu, Jianping, Mao, Dongdong, Hu, Changying, Gao, Dianjun
Format: Article
Language:English
Subjects:
Bias
Biology and Life Sciences
Bladder
Bladder cancer
Cancer
Cancer therapies
Clinical trials
Dosage and administration
Drug therapy
Effectiveness
Engineering and Technology
Evaluation
Hematuria
Heterogeneity
Hyperthermia
Invasiveness
Irritation
Medicine and Health Sciences
Meta-analysis
Mitomycin
Mitomycin C
Patients
Pharmaceutical research
Physical Sciences
Quality of life
Radio frequency
Research and Analysis Methods
Safety
Safety equipment
Side effects
Statistical analysis
Surgery
Testing
Tumors
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Summary:Background This review and meta-analysis aimed to systematically evaluate the clinical efficacy and safety of equipment-assisted intravesical instillation of mitomycin C (MMC) in patients with nonmuscular invasive bladder cancer (NMIBC) after transurethral resection of bladder tumour (TURBT). Methods The Embase, PubMed, CNKI, CBM, WANGFANG, VIP, Cochrane Library, and Clinicaltrial.com databases were searched for articles published before April 2022. The experimental group was treated with intravesical instillation of MMC assisted by equipment, including radiofrequency-induced thermochemotherapy, conductive thermochemical therapy, electromotive drug administration, or locoregional hyperthermia. The control group was treated with simple MMC perfusion. The outcomes of interest in the meta-analysis were recurrence, progression, side-effects, gross haematuria, and bladder irritation. Results A total of 15 studies that enrolled 1,190 patients were included in the meta-analysis. Compared to that of the control group, device-assisted intravesical instillation of MMC significantly reduced both tumour recurrence (odds ratio [OR] = 0.32, 95% confidence interval [CI] [0.24, 0.42], P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0276453