Responses towards eyefluke (Diplostomum pseudospathaceum) in different genetic lineages of rainbow trout

Marker-assisted selective breeding of fish with higher levels of resistance towards specific pathogens may improve fish health, but the impact of host genotype on susceptibility to multiple pathogen infections is still poorly investigated. This study examined the resistance in rainbow trout Oncorhyn...

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Bibliographic Details
Published in:PloS one 2022-10, Vol.17 (10), p.e0276895-e0276895
Main Authors: Karami, Asma M, Duan, Yajiao, Kania, Per W, Buchmann, Kurt
Format: Article
Language:English
Subjects:
Bacterial infections
Biology and Life Sciences
Diplostomum pseudospathaceum
Disease resistance
Experiments
Eye infections
Fish
Fish hatcheries
Gene expression
Genetic aspects
Genomes
Genotypes
Health aspects
Infections
Medicine and Health Sciences
Mollusks
Oncorhynchus mykiss
Parasites
Parasitic diseases
Pathogens
Prevention
Rainbow trout
Salmon
Selective breeding
Single-nucleotide polymorphism
Skin
Sperm
Trout
Viral infections
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Summary:Marker-assisted selective breeding of fish with higher levels of resistance towards specific pathogens may improve fish health, but the impact of host genotype on susceptibility to multiple pathogen infections is still poorly investigated. This study examined the resistance in rainbow trout Oncorhynchus mykiss towards infection with the eye fluke Diplostomum pseudospathaceum. We used genetically selected rainbow trout, carrying SNPs associated with resistance towards the parasitic ciliate Ichthyophthirius multifiliis, and exposed the fish to eye fluke cercariae. We showed that fish partly resistant to I. multifiliis were more susceptible to eye fluke invasion. The expression of immune relevant genes (encoding innate and adaptive factors) was also affected as these genotypes responded less strongly to a secondary fluke infection. The complexity of genome architecture in disease resistance towards multiple pathogens is discussed.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0276895