Reducing the risk of transfusion-transmitted infectious disease markers in blood and blood component donations: Movement from remunerated to voluntary, non-remunerated donations in Lithuania from 2013 to 2020

Lithuania has a long history of remunerated donations. The first steps towards voluntary, non-remunerated blood and blood component donations started in 2004. Lithuania achieved 99.98% voluntary non-remunerated donations (VNRDs) in 2020. This study aimed to assess the risk of transfusion-transmitted...

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Published in:PloS one 2022-11, Vol.17 (11), p.e0277650-e0277650
Main Authors: Kalibatas, Vytenis, Kalibatienė, Lina
Format: Article
Language:English
Subjects:
Antigens
Biology and Life Sciences
Blood
Blood & organ donations
Blood Donors
Communicable Diseases
Disease transmission
Health risks
Hepatitis B
Hepatitis B surface antigen
Hepatitis C
HIV
HIV Infections - epidemiology
HIV Infections - prevention & control
HIV Seropositivity
HIV-1
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Lithuania - epidemiology
Markers
Medicine and Health Sciences
People and places
Prevention
Risk assessment
Safety and security measures
Serology
Sexually transmitted diseases
STD
Syphilis
Syphilis - epidemiology
Transfusion
Transfusion Reaction
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Kalibatienė, Lina
description Lithuania has a long history of remunerated donations. The first steps towards voluntary, non-remunerated blood and blood component donations started in 2004. Lithuania achieved 99.98% voluntary non-remunerated donations (VNRDs) in 2020. This study aimed to assess the risk of transfusion-transmitted infectious (TTI) disease markers for remunerated donations in comparison with VNRDs in Lithuania from 2013 to 2020. Data were obtained from the Lithuanian Blood Donor Register. The prevalence was calculated as the rate between the number of confirmed positive results for all TTI disease markers (serological anti-HCV, HBsAg, Ag/anti-HIV 1 and 2, and syphilis, and/or HCV, HBV, and HIV-1 NAT) per 100 donations. The relative risk of infectious disease markers for remunerated donations was then estimated. In total, 796310 donations were made. Altogether, 2743 donations were positive for TTI markers as follows: HCV, 1318; HBV, 768; syphilis, 583; and HIV 1 and 2, 74. The prevalence of confirmed TTI markers were 2.86, 0.97, 0.18, and 0.04 per 100 first-time remunerated donations, first-time VNRDs, repeat remunerated donations, and repeat VNRDs, respectively. Remunerated first-time and repeat donations had a statistically higher prevalence of TTI disease markers than VNRDs. First-time and repeat remunerated donations had statistically significantly higher relative risks of confirmed TTI disease markers than VNRD. In conclusion, the risks of TTI disease markers for remunerated first-time and repeat blood and its component donations are significantly higher than those for VNRDs.
doi_str_mv 10.1371/journal.pone.0277650
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The first steps towards voluntary, non-remunerated blood and blood component donations started in 2004. Lithuania achieved 99.98% voluntary non-remunerated donations (VNRDs) in 2020. This study aimed to assess the risk of transfusion-transmitted infectious (TTI) disease markers for remunerated donations in comparison with VNRDs in Lithuania from 2013 to 2020. Data were obtained from the Lithuanian Blood Donor Register. The prevalence was calculated as the rate between the number of confirmed positive results for all TTI disease markers (serological anti-HCV, HBsAg, Ag/anti-HIV 1 and 2, and syphilis, and/or HCV, HBV, and HIV-1 NAT) per 100 donations. The relative risk of infectious disease markers for remunerated donations was then estimated. In total, 796310 donations were made. Altogether, 2743 donations were positive for TTI markers as follows: HCV, 1318; HBV, 768; syphilis, 583; and HIV 1 and 2, 74. 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Kalibatienė, Lina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ebafc353226cfe9af8b9746363f3d71ebb5226b2c9c528dc7b33862895b054323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antigens</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood &amp; organ donations</topic><topic>Blood Donors</topic><topic>Communicable Diseases</topic><topic>Disease transmission</topic><topic>Health risks</topic><topic>Hepatitis B</topic><topic>Hepatitis B surface antigen</topic><topic>Hepatitis C</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - prevention &amp; control</topic><topic>HIV Seropositivity</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lithuania - epidemiology</topic><topic>Markers</topic><topic>Medicine and Health Sciences</topic><topic>People and places</topic><topic>Prevention</topic><topic>Risk assessment</topic><topic>Safety and security measures</topic><topic>Serology</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Syphilis</topic><topic>Syphilis - epidemiology</topic><topic>Transfusion</topic><topic>Transfusion Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalibatas, Vytenis</creatorcontrib><creatorcontrib>Kalibatienė, Lina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale_Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; 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The first steps towards voluntary, non-remunerated blood and blood component donations started in 2004. Lithuania achieved 99.98% voluntary non-remunerated donations (VNRDs) in 2020. This study aimed to assess the risk of transfusion-transmitted infectious (TTI) disease markers for remunerated donations in comparison with VNRDs in Lithuania from 2013 to 2020. Data were obtained from the Lithuanian Blood Donor Register. The prevalence was calculated as the rate between the number of confirmed positive results for all TTI disease markers (serological anti-HCV, HBsAg, Ag/anti-HIV 1 and 2, and syphilis, and/or HCV, HBV, and HIV-1 NAT) per 100 donations. The relative risk of infectious disease markers for remunerated donations was then estimated. In total, 796310 donations were made. Altogether, 2743 donations were positive for TTI markers as follows: HCV, 1318; HBV, 768; syphilis, 583; and HIV 1 and 2, 74. The prevalence of confirmed TTI markers were 2.86, 0.97, 0.18, and 0.04 per 100 first-time remunerated donations, first-time VNRDs, repeat remunerated donations, and repeat VNRDs, respectively. Remunerated first-time and repeat donations had a statistically higher prevalence of TTI disease markers than VNRDs. First-time and repeat remunerated donations had statistically significantly higher relative risks of confirmed TTI disease markers than VNRD. In conclusion, the risks of TTI disease markers for remunerated first-time and repeat blood and its component donations are significantly higher than those for VNRDs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36378657</pmid><doi>10.1371/journal.pone.0277650</doi><tpages>e0277650</tpages><orcidid>https://orcid.org/0000-0002-5923-8166</orcidid><oa>free_for_read</oa></addata></record>
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1932-6203
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source PubMed (Medline); Publicly Available Content Database (Proquest) (PQ_SDU_P3)
subjects Antigens
Biology and Life Sciences
Blood
Blood & organ donations
Blood Donors
Communicable Diseases
Disease transmission
Health risks
Hepatitis B
Hepatitis B surface antigen
Hepatitis C
HIV
HIV Infections - epidemiology
HIV Infections - prevention & control
HIV Seropositivity
HIV-1
Human immunodeficiency virus
Humans
Infections
Infectious diseases
Lithuania - epidemiology
Markers
Medicine and Health Sciences
People and places
Prevention
Risk assessment
Safety and security measures
Serology
Sexually transmitted diseases
STD
Syphilis
Syphilis - epidemiology
Transfusion
Transfusion Reaction
title Reducing the risk of transfusion-transmitted infectious disease markers in blood and blood component donations: Movement from remunerated to voluntary, non-remunerated donations in Lithuania from 2013 to 2020
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