Antimicrobial resistance in shigellosis: A surveillance study among urban and rural children over 20 years in Bangladesh

Antimicrobial resistance against shigellosis is increasingly alarming. However, evidence-based knowledge gaps regarding the changing trends of shigellosis in Bangladesh exist due to the scarcity of longitudinal data on antimicrobial resistance. Our study evaluated the last 20 years antimicrobial res...

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Bibliographic Details
Published in:PloS one 2022-11, Vol.17 (11), p.e0277574-e0277574
Main Authors: Nuzhat, Sharika, Das, Rina, Das, Subhasish, Islam, Shoeb Bin, Palit, Parag, Haque, Md Ahshanul, Chakraborty, Subhra, Khan, Soroar Hossain, Ahmed, Dilruba, Alam, Baharul, Ahmed, Tahmeed, Chisti, Mohammod Jobayer, Faruque, A S G
Format: Article
Language:English
Subjects:
Amdinocillin
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Azithromycin
Bangladesh - epidemiology
Biology and Life Sciences
Care and treatment
Caregivers
Ceftriaxone
Child
Children
Ciprofloxacin
Ciprofloxacin - therapeutic use
Diagnosis
Diarrhea
Diarrhea - epidemiology
Distribution
Dosage and administration
Drug resistance
Drug resistance in microorganisms
Drug Resistance, Bacterial
Drugs
Dysentery, Bacillary - drug therapy
Dysentery, Bacillary - epidemiology
Ecology and Environmental Sciences
Health aspects
Hospitals, Rural
Humans
Matlab
Medical laboratories
Medicine and Health Sciences
Multidrug resistance
Multidrug resistant organisms
Parents & parenting
Pathogens
Patients
Prevention
Public health
Regression analysis
Rural areas
Salmonella
Sex
Shigellosis
Statistical analysis
Surveillance systems
Therapeutic applications
Urban areas
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Summary:Antimicrobial resistance against shigellosis is increasingly alarming. However, evidence-based knowledge gaps regarding the changing trends of shigellosis in Bangladesh exist due to the scarcity of longitudinal data on antimicrobial resistance. Our study evaluated the last 20 years antimicrobial resistance patterns against shigellosis among under-5 children in the urban and rural sites of Bangladesh. Data were extracted from the Diarrheal Disease Surveillance System (DDSS) of Dhaka Hospital (urban site) and Matlab Hospital (rural site) of the International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) between January 2001 and December 2020. We studied culture-confirmed shigellosis cases from urban Dhaka Hospital (n = 883) and rural Matlab Hospital (n = 1263). Since 2001, a declining percentage of shigellosis in children observed in urban and rural sites. Moreover, higher isolation rates of Shigella were found in the rural site [1263/15684 (8.1%)] compared to the urban site [883/26804 (3.3%)] in the last 20 years. In both areas, S. flexneri was the predominant species. The upward trend of S. sonnei in both the study sites was statistically significant after adjusting for age and sex. WHO-recommended 1st line antibiotic ciprofloxacin resistance gradually reached more than 70% in both the urban and rural site by 2020. In multiple logistic regression after adjusting for age and sex, ciprofloxacin, azithromycin, mecillinam, ceftriaxone, and multidrug resistance (resistance to any two of these four drugs) among under-5 children were found to be increasing significantly (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0277574