Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder

Disruptions of the cortico-striato-thalamo-cortical circuit has been implicated in both attention-deficit/hyperactivity disorder and substance use disorder. Given the high prevalence of cannabis use among patients with attention-deficit/hyperactivity disorder, we set out to investigate the relations...

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Published in:PloS one 2022-11, Vol.17 (11), p.e0278162-e0278162
Main Authors: Lee, Sanghyun, Hong, Soon-Beom
Format: Article
Language:English
Subjects:
Addictions
Adult
Adults
Analgesics
Attention Deficit Disorder with Hyperactivity - diagnostic imaging
Attention deficit hyperactivity disorder
Biology and Life Sciences
Cannabinoid Receptor Agonists
Cannabis
Cannabis - adverse effects
Childhood
Children
Circuits
Complications and side effects
Computer and Information Sciences
Data collection
Datasets
Diagnosis
Drug abuse
Drug use
Engineering and Technology
Females
Functional magnetic resonance imaging
Hallucinogens
Health risks
Humans
Hyperactivity
Magnetic resonance
Magnetic resonance imaging
Male
Males
Marijuana
Medicine and Health Sciences
Mental disorders
Psychological aspects
Questionnaires
Risk factors
Risk reduction
Social Sciences
Substance abuse
Substance use
Substance use disorder
Thalamus
Young adults
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Hong, Soon-Beom
description Disruptions of the cortico-striato-thalamo-cortical circuit has been implicated in both attention-deficit/hyperactivity disorder and substance use disorder. Given the high prevalence of cannabis use among patients with attention-deficit/hyperactivity disorder, we set out to investigate the relationship between the two in the thalamus. We analyzed resting-state functional magnetic resonance imaging data obtained from the Addiction Connectome Preprocessed Initiative Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder database. Functional connectivity maps were extracted to compare thalamic connectivity among adults who had been diagnosed with attention-deficit/hyperactivity disorder during childhood according to whether or not they used cannabis. The study participants included 18 cannabis users and 15 cannabis non-users with childhood attention-deficit/hyperactivity disorder. Our results revealed that adults with attention-deficit/hyperactivity disorder who used cannabis (n = 18) had significantly decreased functional connectivity between the thalamus and parietal regions, which was particularly prominent in the inferior parietal areas, in comparison with those who did not use cannabis (n = 15). Left thalamic functional connectivity with the inferior parietal and middle frontal areas and right thalamic functional connectivity with the inferior parietal and superior frontal areas were increased in non-users of cannabis with attention-deficit/hyperactivity disorder compared with a local normative comparison group (n = 7). In conclusion, adults with a childhood history of attention-deficit/hyperactivity disorder who do not use cannabis often have relatively stronger thalamoparietal and thalamofrontal connectivity, which may help reduce the risk of cannabis use.
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Hong, Soon-Beom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-390c288fc56872170908c7d9d8f2e7211d3685c31d4e08e61359be0352da028f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Addictions</topic><topic>Adult</topic><topic>Adults</topic><topic>Analgesics</topic><topic>Attention Deficit Disorder with Hyperactivity - diagnostic imaging</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Biology and Life Sciences</topic><topic>Cannabinoid Receptor Agonists</topic><topic>Cannabis</topic><topic>Cannabis - adverse effects</topic><topic>Childhood</topic><topic>Children</topic><topic>Circuits</topic><topic>Complications and side effects</topic><topic>Computer and Information Sciences</topic><topic>Data collection</topic><topic>Datasets</topic><topic>Diagnosis</topic><topic>Drug abuse</topic><topic>Drug use</topic><topic>Engineering and Technology</topic><topic>Females</topic><topic>Functional magnetic resonance imaging</topic><topic>Hallucinogens</topic><topic>Health risks</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Males</topic><topic>Marijuana</topic><topic>Medicine and Health Sciences</topic><topic>Mental disorders</topic><topic>Psychological aspects</topic><topic>Questionnaires</topic><topic>Risk factors</topic><topic>Risk reduction</topic><topic>Social Sciences</topic><topic>Substance abuse</topic><topic>Substance use</topic><topic>Substance use disorder</topic><topic>Thalamus</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sanghyun</creatorcontrib><creatorcontrib>Hong, Soon-Beom</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; 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Given the high prevalence of cannabis use among patients with attention-deficit/hyperactivity disorder, we set out to investigate the relationship between the two in the thalamus. We analyzed resting-state functional magnetic resonance imaging data obtained from the Addiction Connectome Preprocessed Initiative Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder database. Functional connectivity maps were extracted to compare thalamic connectivity among adults who had been diagnosed with attention-deficit/hyperactivity disorder during childhood according to whether or not they used cannabis. The study participants included 18 cannabis users and 15 cannabis non-users with childhood attention-deficit/hyperactivity disorder. Our results revealed that adults with attention-deficit/hyperactivity disorder who used cannabis (n = 18) had significantly decreased functional connectivity between the thalamus and parietal regions, which was particularly prominent in the inferior parietal areas, in comparison with those who did not use cannabis (n = 15). Left thalamic functional connectivity with the inferior parietal and middle frontal areas and right thalamic functional connectivity with the inferior parietal and superior frontal areas were increased in non-users of cannabis with attention-deficit/hyperactivity disorder compared with a local normative comparison group (n = 7). In conclusion, adults with a childhood history of attention-deficit/hyperactivity disorder who do not use cannabis often have relatively stronger thalamoparietal and thalamofrontal connectivity, which may help reduce the risk of cannabis use.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36441710</pmid><doi>10.1371/journal.pone.0278162</doi><tpages>e0278162</tpages><orcidid>https://orcid.org/0000-0003-1030-0763</orcidid><oa>free_for_read</oa></addata></record>
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subjects Addictions
Adult
Adults
Analgesics
Attention Deficit Disorder with Hyperactivity - diagnostic imaging
Attention deficit hyperactivity disorder
Biology and Life Sciences
Cannabinoid Receptor Agonists
Cannabis
Cannabis - adverse effects
Childhood
Children
Circuits
Complications and side effects
Computer and Information Sciences
Data collection
Datasets
Diagnosis
Drug abuse
Drug use
Engineering and Technology
Females
Functional magnetic resonance imaging
Hallucinogens
Health risks
Humans
Hyperactivity
Magnetic resonance
Magnetic resonance imaging
Male
Males
Marijuana
Medicine and Health Sciences
Mental disorders
Psychological aspects
Questionnaires
Risk factors
Risk reduction
Social Sciences
Substance abuse
Substance use
Substance use disorder
Thalamus
Young adults
title Thalamocortical functional connectivity and cannabis use in men with childhood attention-deficit/hyperactivity disorder
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