lron-11 guides axons in the ventral nerve cord of Caenorhabditis elegans

For the nervous system to develop properly, neurons must connect in a precise way to form functional networks. This requires that outgrowing neuronal processes (axons) navigate to their target areas, where they establish proper synaptic connections. The molecular basis of this navigation process is...

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Bibliographic Details
Published in:PloS one 2022-11, Vol.17 (11), p.e0278258-e0278258
Main Authors: Kokan, Nikolas, Witt, Skyla, Sandhu, Saru, Hutter, Harald
Format: Article
Language:English
Subjects:
Animals
Axon guidance
Axonogenesis
Axons
Biology and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Cone-Rod Dystrophies
Developmental neurology
Genetic aspects
Interneurons
Leucine
Membrane proteins
Motor Neurons
Mutation
Nerves
Nervous system
Neurites
Neurons
Physiological aspects
Proteins
Receptors
Research and Analysis Methods
Signal transduction
Synapses
Systems development
Ventral nerve cord
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Summary:For the nervous system to develop properly, neurons must connect in a precise way to form functional networks. This requires that outgrowing neuronal processes (axons) navigate to their target areas, where they establish proper synaptic connections. The molecular basis of this navigation process is not firmly understood. A candidate family containing putative receptors acting in various aspects of neuronal development including axon navigation are transmembrane proteins of the extracellular Leucine-Rich Repeat family (eLRRs). We systematically tested members of this family in C. elegans for a role in axon navigation in the ventral nerve cord (VNC). We found that lron-11 mutants showed VNC navigation defects in several classes of neurons, including a pioneer neuron and various classes of interneurons and motoneurons. This suggests that while most members of the lron-family do not seem to have a role in axon navigation in the VNC, lron-11 is likely to be a receptor required for correct navigation of axons in the VNC of C. elegans.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0278258