Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer

Increasing evidence from epidemiological studies indicate that Alzheimer's disease (AD) has a negative relationship with the incidence of cancers. Whether the Alzheimer's genetic risk factor, named as fermitin family homolog-2 (FERMT2), plays a pivotal part in the progressive process of co...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-12, Vol.17 (12), p.e0278774-e0278774
Main Authors: Xia, Wenzhen, Gao, Zhaoyu, Jiang, Xia, Jiang, Lei, Qin, Yushi, Zhang, Di, Tian, Pei, Wang, Wanchang, Zhang, Qi, Zhang, Rui, Zhang, Nan, Xu, Shunjiang
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer's disease
beta Catenin - genetics
Biology and Life Sciences
Breast cancer
Cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Epidemiology
Epithelial-Mesenchymal Transition - genetics
Genomics
Humans
Immune system
Kinases
Medicine and Health Sciences
Membrane Proteins - genetics
Mesenchyme
Mutation
Neurodegenerative diseases
Research and Analysis Methods
Risk analysis
Risk Factors
Signal transduction
Signaling
Wnt protein
Wnt Signaling Pathway
β-Catenin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3
cites cdi_FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3
container_end_page e0278774
container_issue 12
container_start_page e0278774
container_title PloS one
container_volume 17
creator Xia, Wenzhen
Gao, Zhaoyu
Jiang, Xia
Jiang, Lei
Qin, Yushi
Zhang, Di
Tian, Pei
Wang, Wanchang
Zhang, Qi
Zhang, Rui
Zhang, Nan
Xu, Shunjiang
description Increasing evidence from epidemiological studies indicate that Alzheimer's disease (AD) has a negative relationship with the incidence of cancers. Whether the Alzheimer's genetic risk factor, named as fermitin family homolog-2 (FERMT2), plays a pivotal part in the progressive process of colorectal carcinoma (CRC) yet remains unclear. This study revealed that FERMT2 was upregulated in CRC tissues which predicted an unfavorable outcome of CRC using the PrognoScan web tool. FERMT2 was co-expressed with a variety of genes have been linked with CRC occurrence and implicated in the infiltration of immune cell in CRC tissues. Overexpressing FERMT2 promoted CRC progression with upregulation of Wnt/β-catenin signaling. Knockdown of FERMT2 suppressed the cell multiplication, colony formation rate, migration and invasion, along with the epithelial to mesenchymal transition (EMT) with downregulation Wnt/β-catenin proteins in cells of CRC, while overexpressing β-catenin reversed the inhibitory effects of silencing FERMT2 on the migration or invasion of CRC cells. Furthermore, Aβ1-42 treated HT22 cells induced downregulation of FERMT2 and inhibited the migration, invasion and EMT in co-cultured CT26 cells through Wnt/β-catenin signaling. Our results revealed that the downregulated FERMT2 gene during AD is prominently activated in CRC, which promotes its progression via Wnt/β-catenin pathway.
doi_str_mv 10.1371/journal.pone.0278774
format article
fullrecord <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_2748260698</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_4cb9022f4ec442f3958d97af972bdb3d</doaj_id><sourcerecordid>2753291163</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3</originalsourceid><addsrcrecordid>eNptUstuFDEQHCEQCYE_QGCJA1x2M2PPy5dIUZRApCAktBJHq-1pz3qZsRfbu1H4LO78At-E95FVgji53V1VXd3qLHtd5NOCNcXpwq28hWG6dBanOW3apimfZMcFZ3RS05w9fRAfZS9CWOR5xdq6fp4dsbps06c5zn6fDz_naEb07wPxJnwnGlR0nlxdfv08o2Tp3egiBhLnuPn0HkMwzhKniXKD86giDESBV8a6EcjaAPlm4-mfXxMFEa2xJJg-GTW2J0uI81u4I2C7xLbRG7nairutvsUeolljqnmPQ4pTI4nxFtGSg9EdG6xC_zJ7pmEI-Gr_nmSzq8vZxafJzZeP1xfnNxNV0TpOZMFy7FqtgUreFLyuc8Y5yLbjEpF3LdeMdVIxzdpO5jUHWpW6SgmsSiXZSfZ2J7scXBD7xQdBm7KldYK3CXG9Q3QOFmLpzQj-TjgwYptwvhfgo1EDiiTIc0p1iaosqWa8SjYa0LyhspOsS1pn-24rOWKnMO0JhkeijyvWzEXv1oI3rCg5SwIf9gLe_VhhiGI0QeEwgEW32viuGOVFUW-g7_6B_n-6codS3oXgUR_MFLnYHOM9S2yOUeyPMdHePBzkQLq_PvYXOLbkIQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2748260698</pqid></control><display><type>article</type><title>Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Xia, Wenzhen ; Gao, Zhaoyu ; Jiang, Xia ; Jiang, Lei ; Qin, Yushi ; Zhang, Di ; Tian, Pei ; Wang, Wanchang ; Zhang, Qi ; Zhang, Rui ; Zhang, Nan ; Xu, Shunjiang</creator><contributor>André, Frédéric</contributor><creatorcontrib>Xia, Wenzhen ; Gao, Zhaoyu ; Jiang, Xia ; Jiang, Lei ; Qin, Yushi ; Zhang, Di ; Tian, Pei ; Wang, Wanchang ; Zhang, Qi ; Zhang, Rui ; Zhang, Nan ; Xu, Shunjiang ; André, Frédéric</creatorcontrib><description>Increasing evidence from epidemiological studies indicate that Alzheimer's disease (AD) has a negative relationship with the incidence of cancers. Whether the Alzheimer's genetic risk factor, named as fermitin family homolog-2 (FERMT2), plays a pivotal part in the progressive process of colorectal carcinoma (CRC) yet remains unclear. This study revealed that FERMT2 was upregulated in CRC tissues which predicted an unfavorable outcome of CRC using the PrognoScan web tool. FERMT2 was co-expressed with a variety of genes have been linked with CRC occurrence and implicated in the infiltration of immune cell in CRC tissues. Overexpressing FERMT2 promoted CRC progression with upregulation of Wnt/β-catenin signaling. Knockdown of FERMT2 suppressed the cell multiplication, colony formation rate, migration and invasion, along with the epithelial to mesenchymal transition (EMT) with downregulation Wnt/β-catenin proteins in cells of CRC, while overexpressing β-catenin reversed the inhibitory effects of silencing FERMT2 on the migration or invasion of CRC cells. Furthermore, Aβ1-42 treated HT22 cells induced downregulation of FERMT2 and inhibited the migration, invasion and EMT in co-cultured CT26 cells through Wnt/β-catenin signaling. Our results revealed that the downregulated FERMT2 gene during AD is prominently activated in CRC, which promotes its progression via Wnt/β-catenin pathway.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0278774</identifier><identifier>PMID: 36480537</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alzheimer Disease - genetics ; Alzheimer's disease ; beta Catenin - genetics ; Biology and Life Sciences ; Breast cancer ; Cancer ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Epidemiology ; Epithelial-Mesenchymal Transition - genetics ; Genomics ; Humans ; Immune system ; Kinases ; Medicine and Health Sciences ; Membrane Proteins - genetics ; Mesenchyme ; Mutation ; Neurodegenerative diseases ; Research and Analysis Methods ; Risk analysis ; Risk Factors ; Signal transduction ; Signaling ; Wnt protein ; Wnt Signaling Pathway ; β-Catenin</subject><ispartof>PloS one, 2022-12, Vol.17 (12), p.e0278774-e0278774</ispartof><rights>Copyright: © 2022 Xia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>2022 Xia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Xia et al 2022 Xia et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3</citedby><cites>FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3</cites><orcidid>0000-0002-9441-3900</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2748260698/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2748260698?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36480537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>André, Frédéric</contributor><creatorcontrib>Xia, Wenzhen</creatorcontrib><creatorcontrib>Gao, Zhaoyu</creatorcontrib><creatorcontrib>Jiang, Xia</creatorcontrib><creatorcontrib>Jiang, Lei</creatorcontrib><creatorcontrib>Qin, Yushi</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Tian, Pei</creatorcontrib><creatorcontrib>Wang, Wanchang</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Xu, Shunjiang</creatorcontrib><title>Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Increasing evidence from epidemiological studies indicate that Alzheimer's disease (AD) has a negative relationship with the incidence of cancers. Whether the Alzheimer's genetic risk factor, named as fermitin family homolog-2 (FERMT2), plays a pivotal part in the progressive process of colorectal carcinoma (CRC) yet remains unclear. This study revealed that FERMT2 was upregulated in CRC tissues which predicted an unfavorable outcome of CRC using the PrognoScan web tool. FERMT2 was co-expressed with a variety of genes have been linked with CRC occurrence and implicated in the infiltration of immune cell in CRC tissues. Overexpressing FERMT2 promoted CRC progression with upregulation of Wnt/β-catenin signaling. Knockdown of FERMT2 suppressed the cell multiplication, colony formation rate, migration and invasion, along with the epithelial to mesenchymal transition (EMT) with downregulation Wnt/β-catenin proteins in cells of CRC, while overexpressing β-catenin reversed the inhibitory effects of silencing FERMT2 on the migration or invasion of CRC cells. Furthermore, Aβ1-42 treated HT22 cells induced downregulation of FERMT2 and inhibited the migration, invasion and EMT in co-cultured CT26 cells through Wnt/β-catenin signaling. Our results revealed that the downregulated FERMT2 gene during AD is prominently activated in CRC, which promotes its progression via Wnt/β-catenin pathway.</description><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>beta Catenin - genetics</subject><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Epidemiology</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Genomics</subject><subject>Humans</subject><subject>Immune system</subject><subject>Kinases</subject><subject>Medicine and Health Sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Mesenchyme</subject><subject>Mutation</subject><subject>Neurodegenerative diseases</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Wnt protein</subject><subject>Wnt Signaling Pathway</subject><subject>β-Catenin</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUstuFDEQHCEQCYE_QGCJA1x2M2PPy5dIUZRApCAktBJHq-1pz3qZsRfbu1H4LO78At-E95FVgji53V1VXd3qLHtd5NOCNcXpwq28hWG6dBanOW3apimfZMcFZ3RS05w9fRAfZS9CWOR5xdq6fp4dsbps06c5zn6fDz_naEb07wPxJnwnGlR0nlxdfv08o2Tp3egiBhLnuPn0HkMwzhKniXKD86giDESBV8a6EcjaAPlm4-mfXxMFEa2xJJg-GTW2J0uI81u4I2C7xLbRG7nairutvsUeolljqnmPQ4pTI4nxFtGSg9EdG6xC_zJ7pmEI-Gr_nmSzq8vZxafJzZeP1xfnNxNV0TpOZMFy7FqtgUreFLyuc8Y5yLbjEpF3LdeMdVIxzdpO5jUHWpW6SgmsSiXZSfZ2J7scXBD7xQdBm7KldYK3CXG9Q3QOFmLpzQj-TjgwYptwvhfgo1EDiiTIc0p1iaosqWa8SjYa0LyhspOsS1pn-24rOWKnMO0JhkeijyvWzEXv1oI3rCg5SwIf9gLe_VhhiGI0QeEwgEW32viuGOVFUW-g7_6B_n-6codS3oXgUR_MFLnYHOM9S2yOUeyPMdHePBzkQLq_PvYXOLbkIQ</recordid><startdate>20221208</startdate><enddate>20221208</enddate><creator>Xia, Wenzhen</creator><creator>Gao, Zhaoyu</creator><creator>Jiang, Xia</creator><creator>Jiang, Lei</creator><creator>Qin, Yushi</creator><creator>Zhang, Di</creator><creator>Tian, Pei</creator><creator>Wang, Wanchang</creator><creator>Zhang, Qi</creator><creator>Zhang, Rui</creator><creator>Zhang, Nan</creator><creator>Xu, Shunjiang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9441-3900</orcidid></search><sort><creationdate>20221208</creationdate><title>Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer</title><author>Xia, Wenzhen ; Gao, Zhaoyu ; Jiang, Xia ; Jiang, Lei ; Qin, Yushi ; Zhang, Di ; Tian, Pei ; Wang, Wanchang ; Zhang, Qi ; Zhang, Rui ; Zhang, Nan ; Xu, Shunjiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>beta Catenin - genetics</topic><topic>Biology and Life Sciences</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Epidemiology</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Genomics</topic><topic>Humans</topic><topic>Immune system</topic><topic>Kinases</topic><topic>Medicine and Health Sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Mesenchyme</topic><topic>Mutation</topic><topic>Neurodegenerative diseases</topic><topic>Research and Analysis Methods</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Wnt protein</topic><topic>Wnt Signaling Pathway</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Wenzhen</creatorcontrib><creatorcontrib>Gao, Zhaoyu</creatorcontrib><creatorcontrib>Jiang, Xia</creatorcontrib><creatorcontrib>Jiang, Lei</creatorcontrib><creatorcontrib>Qin, Yushi</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Tian, Pei</creatorcontrib><creatorcontrib>Wang, Wanchang</creatorcontrib><creatorcontrib>Zhang, Qi</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Xu, Shunjiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Wenzhen</au><au>Gao, Zhaoyu</au><au>Jiang, Xia</au><au>Jiang, Lei</au><au>Qin, Yushi</au><au>Zhang, Di</au><au>Tian, Pei</au><au>Wang, Wanchang</au><au>Zhang, Qi</au><au>Zhang, Rui</au><au>Zhang, Nan</au><au>Xu, Shunjiang</au><au>André, Frédéric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-12-08</date><risdate>2022</risdate><volume>17</volume><issue>12</issue><spage>e0278774</spage><epage>e0278774</epage><pages>e0278774-e0278774</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Increasing evidence from epidemiological studies indicate that Alzheimer's disease (AD) has a negative relationship with the incidence of cancers. Whether the Alzheimer's genetic risk factor, named as fermitin family homolog-2 (FERMT2), plays a pivotal part in the progressive process of colorectal carcinoma (CRC) yet remains unclear. This study revealed that FERMT2 was upregulated in CRC tissues which predicted an unfavorable outcome of CRC using the PrognoScan web tool. FERMT2 was co-expressed with a variety of genes have been linked with CRC occurrence and implicated in the infiltration of immune cell in CRC tissues. Overexpressing FERMT2 promoted CRC progression with upregulation of Wnt/β-catenin signaling. Knockdown of FERMT2 suppressed the cell multiplication, colony formation rate, migration and invasion, along with the epithelial to mesenchymal transition (EMT) with downregulation Wnt/β-catenin proteins in cells of CRC, while overexpressing β-catenin reversed the inhibitory effects of silencing FERMT2 on the migration or invasion of CRC cells. Furthermore, Aβ1-42 treated HT22 cells induced downregulation of FERMT2 and inhibited the migration, invasion and EMT in co-cultured CT26 cells through Wnt/β-catenin signaling. Our results revealed that the downregulated FERMT2 gene during AD is prominently activated in CRC, which promotes its progression via Wnt/β-catenin pathway.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36480537</pmid><doi>10.1371/journal.pone.0278774</doi><orcidid>https://orcid.org/0000-0002-9441-3900</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2022-12, Vol.17 (12), p.e0278774-e0278774
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2748260698
source Open Access: PubMed Central; Publicly Available Content Database
subjects Alzheimer Disease - genetics
Alzheimer's disease
beta Catenin - genetics
Biology and Life Sciences
Breast cancer
Cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Epidemiology
Epithelial-Mesenchymal Transition - genetics
Genomics
Humans
Immune system
Kinases
Medicine and Health Sciences
Membrane Proteins - genetics
Mesenchyme
Mutation
Neurodegenerative diseases
Research and Analysis Methods
Risk analysis
Risk Factors
Signal transduction
Signaling
Wnt protein
Wnt Signaling Pathway
β-Catenin
title Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T20%3A44%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alzheimer's%20risk%20factor%20FERMT2%20promotes%20the%20progression%20of%20colorectal%20carcinoma%20via%20Wnt/%CE%B2-catenin%20signaling%20pathway%20and%20contributes%20to%20the%20negative%20correlation%20between%20Alzheimer%20and%20cancer&rft.jtitle=PloS%20one&rft.au=Xia,%20Wenzhen&rft.date=2022-12-08&rft.volume=17&rft.issue=12&rft.spage=e0278774&rft.epage=e0278774&rft.pages=e0278774-e0278774&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0278774&rft_dat=%3Cproquest_plos_%3E2753291163%3C/proquest_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c526t-b130ed8ffa2b9719660399ab8d9bee9d89f33dbc3f38db069a254f5bc3e54cb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2748260698&rft_id=info:pmid/36480537&rfr_iscdi=true