Cognitive adverse effects of epilepsy and its predictors attending outpatient department of South Gondar zone hospitals, Amhara Region, Ethiopia 2020 /2021

• Published in: PloS one 2022-12, Vol.17 (12), p.e0278908-e0278908
• Main Authors: Asnakew, Sintayehu, Legas, Getasew, Belete, Amsalu, Admasu, Fitalew Tadele, Yitbarek, Getachew Yideg, Aytenew, Tigabu Munye, Demise, Biruk, Alemu, Eshetie Molla, Alemu, Muluken Adela, Bayih, Wubet Alebachew, Feleke, Dejen Getaneh, Chanie, Ermias Sisay, Birhane, Binyam Munye, Kefale, Demewoz
• Format: Article
• Language: English
• Subjects: Age; Analysis; Anxiety; Attention; Biology and Life Sciences; Cognition; Cognition & reasoning; Cognitive ability; Complications and side effects; Confidence intervals; Convulsions & seizures; Craniocerebral Trauma; Cross-Sectional Studies; Data collection; Epilepsy; Epilepsy - drug therapy; Epilepsy - epidemiology; Ethiopia - epidemiology; Executive function; Head injuries; Hospitals; Humans; Impairment; Intellectual disabilities; Medicine and Health Sciences; Memory; Mental depression; Mental disorders; Mental health; Patient outcomes; Patients; People and Places; Phenobarbital; Phenytoin; Questionnaires; Random sampling; Response rates; Rural populations; Sample size; Sampling techniques; Seizures; Side effects; Social conditions; Statistical analysis; Statistical sampling; Variables
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0278908

Epilepsy is the most common neurologic disorder which is further complicated by neurobehavioral co-morbidities, cognitive impairment, psychiatric disorders, and social problems. However, assessments of cognitive status of epileptic patients are far too low during clinical visits. This calls for early neuropsychological assessment soon after the diagnosis of epilepsy for a better treatment plan and outcome for epileptic patients. This study aimed to assess the cognitive adverse effects of epilepsy and its predictors attending outpatient departments of South Gondar Zone hospitals Amhara region Ethiopia 2020/2021. A multi-center institutional-based cross-sectional study was conducted. A total of 509 respondents were included with a response rate of 93.9%. Previously adapted pretested structured questionnaire was used containing, socio-demographic, clinical, and seizure related factors. Mini-Mental State Examination (MMSE) was used to measure cognitive impairment. A systematic random sampling technique was applied. Data were entered into Epi data version 4.4.2 then exported to SPSS version 24 for analysis. Descriptive statistics, bivariable and multivariable binary logistic regressions with odds ratios and 95% confidence interval were employed. The level of significance of association was determined at a p-value < 0.05. Prevalence of cognitive impairment in this study was 69.2% (95%CI; 65.4, 73.1). Rural residents (AOR = 4.16,95%CI, 1.99,8.67), respondents who couldn't read and write (AOR = 2.62, 95%CI; 1.24, 5.5,) longer duration of seizure disorder (AOR = 4.59,95%CI; 2.01,10.52), taking combined Phenobarbital and Phenytoin (AOR = 4.69,95%CI; 1.88,11.69), having history of head injury (AOR = 3.29,95%CI;1.30,8.32), having depression (AOR = 4.76,95%CI;2.83,7.98), and anxiety (AOR = 3.11,95%CI; 1.58,6.12) were significantly associated with cognitive impairment. Prevalence of cognitive impairment in this study was high. Regular neuropsychiatric assessment of patients with epilepsy should be encouraged especially for those participants with longer durations of illness, who are rural residents, who take combined Phenobarbital and Phenytoin, participants who had a history of head injury, depression, and anxiety.