Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study

In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40-107 years who were followed prospectively from...

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Bibliographic Details
Published in:PloS one 2022-12, Vol.17 (12), p.e0274659-e0274659
Main Authors: Higashizono, Kazuya, Nakatani, Eiji, Hawke, Philip, Fujimoto, Shuhei, Oba, Noriyuki
Format: Article
Language:English
Subjects:
Aged
Biology and life sciences
Calculi
Cerebrovascular diseases
Cholangitis
Cholecystectomy
Cholesterol
Cohort analysis
Cohort Studies
Dementia disorders
Development and progression
Diabetes
Diagnosis
Disease
Employees
Endoscopy
Etiology
Gallbladder
Gallstones
Gallstones - complications
Gallstones - epidemiology
Gastritis
Health insurance industry
Health risks
Health services
Helicobacter infections
Humans
Hypertension
Insurance claims
Japan - epidemiology
Linked Data
Lung diseases
Male
Malignancy
Medical research
Medicine and Health Sciences
Medicine, Experimental
Multivariate analysis
National health insurance
Population
Population studies
Population-based studies
Registration
Regression analysis
Rheumatic diseases
Risk analysis
Risk Factors
Social Sciences
Variables
Weight control
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Summary:In the research literature on factors associated with gallstones, large population-based cohort studies are rare. We carried out a study of this type to explore risk factors for the onset of gallstones. This study included Japanese participants aged 40-107 years who were followed prospectively from January 2012 to September 2020 using a dataset composed of two individually linked databases, one containing annual health checkup records and the other containing medical claims for beneficiaries of the National Health Insurance System and the Medical Care System for Elderly in the Latter Stage of Life in Shizuoka Prefecture, Japan. Among the 611,930 participants in the analysis set, 23,843 (3.9%) were diagnosed with gallstones during the observational period (median [max]: 5.68 [7.5] years). Multivariate analysis revealed that risk of gallstone disease was increased by male sex, cerebrovascular disease, any malignancy, dementia, rheumatic disease, chronic pulmonary disease, hypertension, and H. pylori-infected gastritis. These findings provide essential insights into the etiology of cholelithiasis and may contribute to efforts to reduce the incidence of the disease.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0274659