Non-enveloped virus membrane penetration: New advances leading to new insights

Host cell membranes pose a particular challenge for non-enveloped viruses. Whereas enveloped viruses enter cells by fusing their lipid envelopes with the cellular membrane, non-enveloped viruses generally must (1) enter cells via endocytosis, then (2) penetrate the cellular endomembrane to reach the...

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Bibliographic Details
Published in:PLoS pathogens 2022-12, Vol.18 (12), p.e1010948-e1010948
Main Authors: Pletan, Madison L, Tsai, Billy
Format: Article
Language:English
Subjects:
Acidification
Biology and Life Sciences
Cell interaction
Cell membranes
Cytosol
Endocytosis
Genomes
Host-bacteria relationships
Human papillomavirus
Infections
Lipids
Medicine and Health Sciences
Membranes
Microscopy
Mutation
Papillomaviridae
Pearls
Penetration
Physiological aspects
Proteins
Rotavirus
Viral envelopes
Viral proteins
Virus research
Viruses
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Summary:Host cell membranes pose a particular challenge for non-enveloped viruses. Whereas enveloped viruses enter cells by fusing their lipid envelopes with the cellular membrane, non-enveloped viruses generally must (1) enter cells via endocytosis, then (2) penetrate the cellular endomembrane to reach the cytosol. Only then can the viruses begin to replicate (or transit to the nucleus to replicate). Although membrane penetration of non-enveloped viruses is a crucial entry step, many of the precise molecular details of this process remain unclear. Recent findings have begun to untangle the various mechanisms by which non-enveloped viral proteins disrupt and penetrate cellular endomembranes. Specifically, high-resolution microscopy studies have revealed precise conformational changes in viral proteins that enable penetration, while biochemical studies have identified key host proteins that promote viral penetration and transport. This brief article summarizes new discoveries in the membrane penetration process for three of the most intensely studied families of non-enveloped viruses: reoviruses, papillomaviruses, and polyomaviruses.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010948