Feasibility of a silicone vascular phantom replicating real arterial contrast filling dynamics on cerebral angiography: An in-vitro pilot study

• Published in: PloS one 2023-01, Vol.18 (1), p.e0280395-e0280395
• Main Authors: Lee, Ki Baek, Sheen, Jae Jon, Yoon, Jong-Tae, Kim, Mi Hyeon, Maeng, Jun Young, Hwang, Sun Moon, Choi, Joon Ho, Lee, Deok Hee
• Format: Article
• Language: English
• Subjects: 3-D printers; Angiography; Angiography, Digital Subtraction; Biology and Life Sciences; Blood pressure; Body temperature; Carotid arteries; Catheters; Cerebral Angiography; Cerebral blood flow; Dynamics; Engineering and technology; Feasibility Studies; Health aspects; Hemodynamics; Humans; Iodine; Medical imaging; Medicine and Health Sciences; Methods; Physical Sciences; Pilot Projects; Plastics; Research and Analysis Methods; Silicones; Testing; Veins & arteries; Viscosity; Wound drainage
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0280395

Some cerebral arterial silicone phantoms have been used in preclinical evaluations. However, typical silicone-based phantoms are limited in their capacity to reproduce real contrast filling dynamics of the human cerebral artery. This study aimed to develop a cerebral arterial silicone phantom to analyze the feasibility of real contrast filling dynamics. The fluid circulation phantom system consisted of a cerebral arterial silicone phantom without or with additional devices, a pump, an injection system, a pressure-monitoring system, a constant-temperature bath, and a venous drainage container. Vascular resistance was reproduced with a plastic cistern only or a plastic cistern filled with a sponge pad. Three phantom groups were constructed as follows: a) the cerebral arterial silicone phantom used as the control group (type A), b) phantom with the incorporated plastic cistern (type B), and c) phantom with the incorporated plastic cistern filled with a sponge pad (type C). The contrast concentration-time curve patterns of the three groups obtained from digital subtraction angiography (DSA) were compared. Consequently, the DSA pattern of the type C phantom was the most similar to that obtained from the control group as the reference data, which showed the broadest full-width-at-half-maximum and the area under the curve values and the highest maximum contrast concentration. In conclusion, we could emulate the arterial contrast filling dynamics of clinical cerebral angiography by applying a small cistern filled with a sponge pad at the drainage side of the phantom.