Quality and credibility of clinical practice guidelines recommendations for the management of neonatal hypoglycemia. A protocol for a systematic review and recommendations' synthesis

• Published in: PloS one 2023-01, Vol.18 (1), p.e0280597-e0280597
• Main Authors: Shahid, Shaneela, Cabra-Bautista, Ginna, Florez, Ivan D
• Format: Article
• Language: English
• Subjects: Biology and Life Sciences; Care and treatment; Caribbean Region; Clinical medicine; Clinical practice guidelines; Collaboration; Credibility; Data collection; Databases, Factual; Diagnosis; Domains; Ethics; Evaluation; Evidence-based medicine; Glucose; Glucose metabolism; Guidelines; Health aspects; Health risks; Humans; Hypoglycemia; Infant, Newborn; Infants (Newborn); Intervention; Medicine and Health Sciences; Methods; Neonates; Newborn babies; Practice guidelines (Medicine); Quality assessment; Registration; Research and Analysis Methods; Research Design; Reviews; Study Protocol; Synthesis; Systematic review; Systematic Reviews as Topic
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0280597

Hypoglycemia is one of the most frequent metabolic conditions in neonates. Clinical practice guidelines (CPGs) influence clinical practice as high-quality CPGs facilitate the use of evidence in practice. This proposed study aims to systematically identify and appraise CPGs and CPG recommendations (CPGRs) for treating neonatal hypoglycemia (NH). We will conduct searches in MEDLINE, EMBASE, CINAHL, Cochrane Library, LILACS (Latin American & Caribbean Health Sciences Literature), and Epistemonikos. Authors will search CPGs-specific databases and grey literature. Two reviewers will independently perform the titles and abstract screening, full-text review, and data extraction. Two appraisers will assess the quality of the CPGs and their recommendations using AGREE II (Appraisal of Guidelines Research and Evaluation) and AGREE-REX (Appraisal of Guidelines Research and Evaluation-Recommendations Excellence) instruments. Scores of ≥ 60% in the rigour of development domain will be considered for defining high-quality with AGREE II tool. CPGRs with scores >60% in the three domains will be used to determine high quality with the AGREE REX tool. We will perform a synthesis of the CPGRs to identify the consistency among the CPGRs and the methodological quality of primary studies that support them. The results will help us to identify the methodological and quality gaps in the existing CPGs for the treatment of NH. Our findings will be submitted to peer-review journals and presented at academic conferences. Based on the study design, approval from the institutional ethics board is not required for this project. Systematic Review Registration Number (PROSPERO): CRD 42021239921.