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Quality and credibility of clinical practice guidelines recommendations for the management of neonatal hypoglycemia. A protocol for a systematic review and recommendations' synthesis

Hypoglycemia is one of the most frequent metabolic conditions in neonates. Clinical practice guidelines (CPGs) influence clinical practice as high-quality CPGs facilitate the use of evidence in practice. This proposed study aims to systematically identify and appraise CPGs and CPG recommendations (C...

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Published in:PloS one 2023-01, Vol.18 (1), p.e0280597-e0280597
Main Authors: Shahid, Shaneela, Cabra-Bautista, Ginna, Florez, Ivan D
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Cabra-Bautista, Ginna
Florez, Ivan D
description Hypoglycemia is one of the most frequent metabolic conditions in neonates. Clinical practice guidelines (CPGs) influence clinical practice as high-quality CPGs facilitate the use of evidence in practice. This proposed study aims to systematically identify and appraise CPGs and CPG recommendations (CPGRs) for treating neonatal hypoglycemia (NH). We will conduct searches in MEDLINE, EMBASE, CINAHL, Cochrane Library, LILACS (Latin American & Caribbean Health Sciences Literature), and Epistemonikos. Authors will search CPGs-specific databases and grey literature. Two reviewers will independently perform the titles and abstract screening, full-text review, and data extraction. Two appraisers will assess the quality of the CPGs and their recommendations using AGREE II (Appraisal of Guidelines Research and Evaluation) and AGREE-REX (Appraisal of Guidelines Research and Evaluation-Recommendations Excellence) instruments. Scores of ≥ 60% in the rigour of development domain will be considered for defining high-quality with AGREE II tool. CPGRs with scores >60% in the three domains will be used to determine high quality with the AGREE REX tool. We will perform a synthesis of the CPGRs to identify the consistency among the CPGRs and the methodological quality of primary studies that support them. The results will help us to identify the methodological and quality gaps in the existing CPGs for the treatment of NH. Our findings will be submitted to peer-review journals and presented at academic conferences. Based on the study design, approval from the institutional ethics board is not required for this project. Systematic Review Registration Number (PROSPERO): CRD 42021239921.
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subjects Biology and Life Sciences
Care and treatment
Caribbean Region
Clinical medicine
Clinical practice guidelines
Collaboration
Credibility
Data collection
Databases, Factual
Diagnosis
Domains
Ethics
Evaluation
Evidence-based medicine
Glucose
Glucose metabolism
Guidelines
Health aspects
Health risks
Humans
Hypoglycemia
Infant, Newborn
Infants (Newborn)
Intervention
Medicine and Health Sciences
Methods
Neonates
Newborn babies
Practice guidelines (Medicine)
Quality assessment
Registration
Research and Analysis Methods
Research Design
Reviews
Study Protocol
Synthesis
Systematic review
Systematic Reviews as Topic
title Quality and credibility of clinical practice guidelines recommendations for the management of neonatal hypoglycemia. A protocol for a systematic review and recommendations' synthesis
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