The effect of damage to the white matter network and premorbid intellectual ability on postoperative verbal short-term memory and functional outcome in patients with brain lesions

• Published in: PloS one 2023-01, Vol.18 (1), p.e0280580
• Main Authors: Ebina, Kota, Matsui, Mie, Kinoshita, Masashi, Saito, Daisuke, Nakada, Mitsutoshi
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Analysis; Biology and Life Sciences; Brain - diagnostic imaging; Brain cancer; Brain damage; Brain diseases; Brain injury; Brain Neoplasms - surgery; Brain tumors; Cognition; Cognitive ability; Cognitive Dysfunction; Complications and side effects; Dementia; Diagnosis; Education; Executive function; Hemispheric laterality; Humans; Intelligence; Language; Lesions; Magnetic resonance imaging; Medical prognosis; Medicine and Health Sciences; Memory; Memory, Short-Term; Multiple regression analysis; Neurological diseases; Neuropsychological Tests; Older people; Patients; Phonology; Quality of life; Regression analysis; Risk factors; Short term memory; Social Sciences; Stroke; Substantia alba; Traumatic brain injury; Tumors; White Matter - diagnostic imaging
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0280580

Cognitive reserve is the capacity to cope with cognitive decline due to brain damage caused by neurological diseases. Premorbid IQ has been investigated as a proxy for cognitive reserve. To date, no study has focused on the effects of premorbid IQ in patients with brain tumors, considering the damage to white matter tracts. We investigated whether a higher premorbid IQ has a beneficial impact on postoperative verbal short-term memory and functional outcomes in patients with brain tumors. A total of 65 patients with brain tumors (35 right and 30 left hemisphere lesions) and 65 healthy subjects participated in the study. We used multiple regression analysis to examine whether white matter tract damage and premorbid IQ affect postoperative verbal short-term memory, and the interaction effects of premorbid IQ with damage to white matter tract on postoperative verbal short-term memory. Path analysis was used to investigate the relationship between damage to the white matter tract and premorbid IQ on postoperative functional ability. Our results showed that damage to the left arcuate fasciculus affected postoperative functional ability through verbal short-term memory, working memory, and global cognition in patients with left hemisphere lesions. In the right hemisphere lesion group, high premorbid IQ had a positive effect on functional ability by mediating verbal short-term memory, verbal working memory, and global cognition. We found that damage to the eloquent pathway affected postoperative verbal short-term memory regardless of the premorbid IQ level. However, a higher premorbid IQ was associated with better postoperative verbal short-term memory and functional outcomes when the brain lesions were not located in a crucial pathway. Our findings suggest that premorbid IQ and damage to the white matter tracts should be considered predictors of postoperative functional outcomes.