Progesterone and prolactin levels in pregnant women living with HIV who delivered preterm and low birthweight infants: A nested case-control study

Antiretroviral therapy (ART) is associated with high rates of adverse birth outcomes, including preterm birth and low birthweight. Studies suggest that progesterone and prolactin may play important intermediary roles. We analyzed data from the Antenatal Component of the PROMISE trial, a multi-center...

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Bibliographic Details
Published in:PloS one 2023-01, Vol.18 (1), p.e0280730
Main Authors: Chi, Benjamin H, Sebikari, Dorothy, Brummel, Sean S, DeMarrais, Patricia, Chamanga, Rachel, Owor, Maxensia, Dadabhai, Sufia, Price, Joan T, Taha, Taha, Stringer, Jeffrey, Fowler, Mary Glenn
Format: Article
Language:English
Subjects:
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Babies
Biology and Life Sciences
Birth Weight
Breastfeeding & lactation
Care and treatment
Case-Control Studies
Disease prevention
Disease transmission
Female
Gestation
Gestational age
Health aspects
HIV
HIV Infections - drug therapy
HIV patients
Human immunodeficiency virus
Humans
Infant
Infant, Newborn
Infants
Infectious Disease Transmission, Vertical - prevention & control
Lopinavir
Measurement
Medicine and Health Sciences
Neonates
Newborn babies
People and Places
Plasma
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Pregnant Women
Premature birth
Premature Birth - prevention & control
Prevention
Progesterone
Prolactin
Regression analysis
Risk factors
Ritonavir
Zidovudine
Zidovudine - therapeutic use
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Summary:Antiretroviral therapy (ART) is associated with high rates of adverse birth outcomes, including preterm birth and low birthweight. Studies suggest that progesterone and prolactin may play important intermediary roles. We analyzed data from the Antenatal Component of the PROMISE trial, a multi-center study of pregnant women taking antiretroviral regimens (lopinavir/ritonavir-containing ART or zidovudine alone) to prevent mother-to-child HIV transmission. In a nested case-control study, we compared data from women who gave birth to preterm (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0280730