The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors

CPT1A is a rate-limiting enzyme in fatty acid oxidation and is upregulated in high-risk breast cancer. Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-02, Vol.18 (2), p.e0281252-e0281252
Main Authors: Liu, Ryan, Ospanova, Shyryn, Perry, Rachel J
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Body mass index
Body measurements
Breast cancer
Breast Neoplasms - pathology
Cancer patients
Carnitine
Carnitine O-Palmitoyltransferase - genetics
Carnitine O-Palmitoyltransferase - metabolism
Carnitine palmitoyltransferase
Cell cycle
Computed tomography
Computer and Information Sciences
CT imaging
Datasets
Dependent variables
Enzymes
Fatty acids
Fatty Acids - metabolism
Female
Gene expression
Gene sequencing
Genetic aspects
Genomics
Health aspects
Health risks
Humans
Kidney cancer
Medical prognosis
Medicine and Health Sciences
Menopause
Metabolism
Mortality
Mutation
Obesity
Oxidation
Palmitoyltransferase
PET imaging
Physiological aspects
Positron emission
Positron emission tomography
Premenopause
Prognosis
Research and Analysis Methods
RNA sequencing
Survivability
Tomography
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:CPT1A is a rate-limiting enzyme in fatty acid oxidation and is upregulated in high-risk breast cancer. Obesity and menopausal status' relationship with breast cancer prognosis is well established, but its connection with fatty acid metabolism is not. We utilized RNA sequencing data in the Xena Functional Genomics Explorer, to explore CPT1A's effect on breast cancer patients' survival probability. Using [18F]-fluorothymidine positron emission tomography-computed tomography images from The Cancer Imaging Archive, we segmented these analyses by obesity and menopausal status. In 1214 patients, higher CPT1A expression is associated with lower breast cancer survivability. We confirmed a previously observed protective relationship between obesity and breast cancer in pre-menopausal patients and supported this data using two-sided Pearson correlations. Taken together, these analyses using open-access databases bolster the potential role of CPT1A-dependent fatty acid metabolism as a pathogenic factor in breast cancer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0281252