Modelling of thrombus formation using smoothed particle hydrodynamics method

In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from flu...

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Bibliographic Details
Published in:PloS one 2023-02, Vol.18 (2), p.e0281424-e0281424
Main Authors: Monteleone, Alessandra, Viola, Alessia, Napoli, Enrico, Burriesci, Gaetano
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Blood
Blood clot
Blood clots
Blood clotting
Blood Coagulation
Blood platelets
Cardiovascular research
Computer Simulation
Detention
Detention of persons
Development and progression
Dynamics of a particle
Enzymes
Fluid dynamics
Fluid mechanics
Fluid-structure interaction
Hemodynamics
Humans
Hydrodynamics
Hydrofoil boats
Medicine and Health Sciences
Methods
Modelling
Molecules
Physical Sciences
Physiology
Pulmonary embolisms
Shear stress
Smooth particle hydrodynamics
Solid phases
Thromboembolism
Thrombosis
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Summary:In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0281424