Filamin C is Essential for mammalian myocardial integrity

FLNC, encoding filamin C, is one of the most mutated genes in dilated and hypertrophic cardiomyopathy. However, the precise role of filamin C in mammalian heart remains unclear. In this study, we demonstrated Flnc global (FlncgKO) and cardiomyocyte-specific knockout (FlnccKO) mice died in utero from...

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Published in:PLoS genetics 2023-01, Vol.19 (1), p.e1010630
Main Authors: Wu, Tongbin, Xu, Yujun, Zhang, Lunfeng, Liang, Zhengyu, Zhou, Xiaohai, Evans, Sylvia M, Chen, Ju
Format: Article
Language:English
Subjects:
Animals
Antibodies
Apoptosis
Binding proteins
Biology and Life Sciences
Cardiology
Cardiomyocytes
Cardiomyopathy
Cardiomyopathy, Hypertrophic
Cardiovascular research
Development and progression
Developmental biology
Engineering and Technology
Filamins - genetics
Gene expression
Gene mutations
Genetic aspects
Genotype & phenotype
Health aspects
Heart
Heart diseases
Integrin beta1 - genetics
Integrins
Mammals
Medicine and Health Sciences
Mice
Mutation
Myocardium
Myocytes, Cardiac
Phenotypes
Proteins
Research and Analysis Methods
Ventricle
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Chen, Ju
description FLNC, encoding filamin C, is one of the most mutated genes in dilated and hypertrophic cardiomyopathy. However, the precise role of filamin C in mammalian heart remains unclear. In this study, we demonstrated Flnc global (FlncgKO) and cardiomyocyte-specific knockout (FlnccKO) mice died in utero from severely ruptured ventricular myocardium, indicating filamin C is required to maintain the structural integrity of myocardium in the mammalian heart. Contrary to the common belief that filamin C acts as an integrin inactivator, we observed attenuated activation of β1 integrin specifically in the myocardium of FlncgKO mice. Although deleting β1 integrin from cardiomyocytes did not recapitulate the heart rupture phenotype in Flnc knockout mice, deleting both β1 integrin and filamin C from cardiomyocytes resulted in much more severe heart ruptures than deleting filamin C alone. Our results demonstrated that filamin C works in concert with β1 integrin to maintain the structural integrity of myocardium during mammalian heart development.
doi_str_mv 10.1371/journal.pgen.1010630
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subjects Animals
Antibodies
Apoptosis
Binding proteins
Biology and Life Sciences
Cardiology
Cardiomyocytes
Cardiomyopathy
Cardiomyopathy, Hypertrophic
Cardiovascular research
Development and progression
Developmental biology
Engineering and Technology
Filamins - genetics
Gene expression
Gene mutations
Genetic aspects
Genotype & phenotype
Health aspects
Heart
Heart diseases
Integrin beta1 - genetics
Integrins
Mammals
Medicine and Health Sciences
Mice
Mutation
Myocardium
Myocytes, Cardiac
Phenotypes
Proteins
Research and Analysis Methods
Ventricle
title Filamin C is Essential for mammalian myocardial integrity
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