Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study

To determine the effect of sex on sepsis-related ICU admission and survival for up to 3-years. Retrospective cohort study of adults admitted to Australian ICUs between 2018 and 2020. Men and women with a primary diagnosis of sepsis were included. The primary outcome of time to death for up to 3-year...

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Published in:PloS one 2023-02, Vol.18 (2), p.e0281939-e0281939
Main Authors: Thompson, Kelly, Hammond, Naomi, Bailey, Michael, Darvall, Jai, Low, Gary, McGloughlin, Steven, Modra, Lucy, Pilcher, David
Format: Article
Language:English
Subjects:
Adult
Age groups
Aged
Analysis
Australia
Care and treatment
Chronic fatigue syndrome
Cohort analysis
Cohort Studies
Confidence intervals
Demographic aspects
Female
Frailty
Gender differences
Health risks
Hospital Mortality
Humans
Infection
Infections
Intensive care
Intensive Care Units
Length of Stay
Male
Mechanical ventilation
Medicine and Health Sciences
Men
Mortality
Patient admissions
People and Places
Physical Sciences
Physiology
Retrospective Studies
Sepsis
Severe acute respiratory syndrome coronavirus 2
Sex Characteristics
Sex differences
Socioeconomic factors
Survival
Ventilation
Women
Womens health
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cited_by cdi_FETCH-LOGICAL-c692t-6516a9833aa1fa9f1c8fba4184638026eb8bedd40d31606ef6c67ea75fe62bcc3
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container_issue 2
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container_title PloS one
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creator Thompson, Kelly
Hammond, Naomi
Bailey, Michael
Darvall, Jai
Low, Gary
McGloughlin, Steven
Modra, Lucy
Pilcher, David
description To determine the effect of sex on sepsis-related ICU admission and survival for up to 3-years. Retrospective cohort study of adults admitted to Australian ICUs between 2018 and 2020. Men and women with a primary diagnosis of sepsis were included. The primary outcome of time to death for up to 3-years was examined using Kaplan Meier plots. Secondary outcomes included the duration of ICU and hospital stay. Of 523,576 admissions, there were 63,039 (12·0%) sepsis-related ICU admissions. Of these, there were 50,956 patients (43·4% women) with 3-year survival data. Men were older (mean age 66·5 vs 63·6 years), more commonly received mechanical ventilation (27·4% vs 24·7%) and renal replacement therapy (8·2% vs 6·8%) and had worse survival (Hazard Ratio [HR] 1·11; 95% Confidence Interval [CI] 1·07 to 1·14, P
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language eng
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source PubMed Central Free; ProQuest - Publicly Available Content Database
subjects Adult
Age groups
Aged
Analysis
Australia
Care and treatment
Chronic fatigue syndrome
Cohort analysis
Cohort Studies
Confidence intervals
Demographic aspects
Female
Frailty
Gender differences
Health risks
Hospital Mortality
Humans
Infection
Infections
Intensive care
Intensive Care Units
Length of Stay
Male
Mechanical ventilation
Medicine and Health Sciences
Men
Mortality
Patient admissions
People and Places
Physical Sciences
Physiology
Retrospective Studies
Sepsis
Severe acute respiratory syndrome coronavirus 2
Sex Characteristics
Sex differences
Socioeconomic factors
Survival
Ventilation
Women
Womens health
title Sex differences in long-term survival after intensive care unit treatment for sepsis: A cohort study
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