Process description of developing HIV prevention monitoring indicators for a province-wide pre-exposure prophylaxis (PrEP) program in British Columbia, Canada

• Published in: PloS one 2023-03, Vol.18 (3), p.e0283025
• Main Authors: Munasinghe, Lalani L, Toy, Junine, Lepik, Katherine J, Moore, David M, Hull, Mark, Bacani, Nic, Sereda, Paul, Barrios, Rolando, Montaner, Julio S G, Lima, Viviane D
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - epidemiology; Adverse and side effects; AIDS; Anti-HIV Agents - therapeutic use; Biology and Life Sciences; British Columbia - epidemiology; Clients; Committees; COVID-19; COVID-19 - epidemiology; Disease control; Disease prevention; Drugs; Gender; Health care; Health risks; Health surveillance; HIV; HIV infection; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - prevention & control; Homosexuality, Male; Human immunodeficiency virus; Humans; Indicators; Infections; Initiatives; Male; Mathematical analysis; Medical laboratories; Medicine and Health Sciences; Men; Pandemics; People and Places; Pre-Exposure Prophylaxis; Prevention; Program evaluation; Prophylaxis; Public health; Research ethics; Risk factors; Scientific validity; Sexual and Gender Minorities; Sexually transmitted diseases; STD; Surveillance; Syphilis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0283025

In 2018, the pre-exposure prophylaxis (PrEP) program was initiated in British Columbia (BC), Canada, providing PrEP at no cost to qualifying residents. This observational study discussed the steps to develop key evidence-based monitoring indicators and their calculation using real-time data. The indicators were conceptualized, developed, assessed and approved by the Technical Monitoring Committee of representatives from five health authority regions in BC, the BC Ministry of Health, the BC Centre for Disease Control, and the BC Centre for Excellence in HIV/AIDS. Indicator development followed the steps adopted from the United States Centers for Disease Control and Prevention framework for program evaluation in public health. The assessment involved eight selection criteria: data quality, indicator validity, existing scientific evidence, indicator informativeness, indicator computing feasibility, clients' confidentiality maintenance capacity, indicator accuracy, and administrative considerations. Clients' data from the provincial-wide PrEP program (January 2018-December 2020) shows the indicators' calculation. The finalized 14 indicators included gender, age, health authority, new clients enrolled by provider type and by the health authority, new clients dispensed PrEP, clients per provider, key qualifying HIV risk factor(s), client status, PrEP usage type, PrEP quantity dispensed, syphilis and HIV testing and incident cases, and adverse drug reaction events. Cumulative clients' data (n = 6966; 99% cis-gender males) identified an increased new client enrollment and an unexpected drop during the COVID-19 pandemic. About 80% dispensed PrEP from the Vancouver Coastal health authority. The HIV incidence risk index for men who have sex with men score ≥10 was the most common qualifying risk factor. The framework we developed integrating indicators was applied to monitor our PrEP program, which could help reduce the public health impact of HIV.