Low pre-ART CD4 count is associated with increased risk of clinical progression or death even after reaching 500 CD4 cells/μL on ART

Clinical disadvantages of initiating ART at low CD4 counts have been clearly demonstrated but whether any excess risk remains even after reaching relatively high/safe CD4 levels remains unclear. We explore whether individuals starting ART with

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Bibliographic Details
Published in:PloS one 2023-03, Vol.18 (3), p.e0283648-e0283648
Main Authors: Pantazis, Nikos, Paparizos, Vasilios, Papastamopoulos, Vasilios, Metallidis, Simeon, Antoniadou, Anastasia, Adamis, Georgios, Psichgiou, Mina, Chini, Maria, Sambatakou, Helen, Chrysos, Georgios, Sipsas, Nikolaos V, Gogos, Charalambos, Barbunakis, Emmanouil, Panagopoulos, Periklis, Katsarou, Olga, Touloumi, Giota
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Antiretroviral therapy
Biology and Life Sciences
CD4 antigen
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Cohort analysis
Disease
Disease Progression
Drug therapy
Health risks
HIV
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Hypotheses
Medicine and Health Sciences
Risk
Subgroups
Viral Load
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Description
Summary:Clinical disadvantages of initiating ART at low CD4 counts have been clearly demonstrated but whether any excess risk remains even after reaching relatively high/safe CD4 levels remains unclear. We explore whether individuals starting ART with
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0283648