The histological analysis of the coronary medial thickness: Implications for percutaneous coronary intervention

A deeper understanding of coronary medial thickness is important for coronary intervention because media thickness can limit the safety and effectiveness of interventional techniques. However, there is a paucity of detailed data on human coronary medial thickness so far. We investigated the thicknes...

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Bibliographic Details
Published in:PloS one 2023-03, Vol.18 (3), p.e0283840-e0283840
Main Authors: Konishi, Takao, Ghosh, Saikat Kumar B, Sato, Yu, Kawakami, Rika, Kawai, Kenji, Vozenilek, Aimee E, Xu, Weili, Bellissard, Arielle, Giasolli, Robert, Chahal, Diljon, Virmani, Renu, Finn, Aloke V
Format: Article
Language:English
Subjects:
Aged
Angioplasty
Arteries
Atherosclerosis
Autopsies
Autopsy
Biology and Life Sciences
Calcification
Cardiovascular disease
Care and treatment
Catheters
Coronary Angiography
Coronary arteries
Coronary artery
Coronary vessels
Coronary Vessels - diagnostic imaging
Coronary Vessels - pathology
Diameters
Engineering and Technology
Heart
Humans
Medicine and Health Sciences
Methods
Middle Aged
Normal distribution
Percutaneous Coronary Intervention - methods
Physical Sciences
Physiological aspects
Product development
Review boards
Segments
Statistical analysis
Stents
Thickness
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Summary:A deeper understanding of coronary medial thickness is important for coronary intervention because media thickness can limit the safety and effectiveness of interventional techniques. However, there is a paucity of detailed data on human coronary medial thickness so far. We investigated the thickness of the media by histologic analysis. A total of 230 sections from 10 individuals from the CVPath autopsy registry who died from non-coronary deaths were evaluated. We performed pathological analysis on 13 segments of the following primary vessels from coronary arteries: the left main trunk, proximal left anterior descending artery (LAD), mid LAD, distal LAD, proximal left circumflex artery (LCX), mid LCX, distal LCX, proximal right coronary artery (RCA), mid RCA, and the distal RCA. The following side branches were also evaluated: diagonal, obtuse margin, and posterior descending artery branches. The average age of the studied individuals was 60.4±12.3 years. The median medial thickness for all sections was 0.202 (0.149-0.263) mm. The median medial thickness of the main branches was significantly higher compared to that of the side branches (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0283840