Artemisinin suppresses aerobic glycolysis in thyroid cancer cells by downregulating HIF-1a, which is increased by the XIST/miR-93/HIF-1a pathway

The incidence of thyroid cancer (TC) continues to increase worldwide. Aerobic glycolysis, the prominent feature of glucose metabolism in cancer progression, is associated with TC. We first demonstrated that HIF-1a is highly expressed in TC tissues and is positively correlated with the level of XIST...

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Bibliographic Details
Published in:PloS one 2023-04, Vol.18 (4), p.e0284242-e0284242
Main Authors: Yang, Fei, Zhang, Jie, Zhao, Zhijun, Liu, Yan, Zhao, Zhen, Fu, Kai, Li, Baokun, Jin, Jing
Format: Article
Language:English
Subjects:
Antibodies
Artemisinin
Artemisinins - pharmacology
Biology and Life Sciences
Cancer
Cancer therapies
Cell cycle
Cell Line, Tumor
Cell Proliferation
Cellular control mechanisms
Development and progression
Drug therapy
Glucose metabolism
Glycolysis
Health aspects
Humans
Hypoxia-inducible factor 1a
Infrared imaging systems
Lymphatic system
Medicine and Health Sciences
Metabolism
Metastases
Metastasis
MicroRNAs - genetics
MicroRNAs - metabolism
Mutation
Proteins
Radiation
Research and Analysis Methods
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Thyroid
Thyroid cancer
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - genetics
Thyroid Neoplasms - metabolism
Transcription factors
Tumor markers
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Summary:The incidence of thyroid cancer (TC) continues to increase worldwide. Aerobic glycolysis, the prominent feature of glucose metabolism in cancer progression, is associated with TC. We first demonstrated that HIF-1a is highly expressed in TC tissues and is positively correlated with the level of XIST in the serum of patients with TC. Then, we proved that XIST regulates the expression of HIF-1a through the XIST/miR-93/HIF-1a pathway, thereby regulating the level of glycolysis in TC cells. Knockdown of XIST inhibits glycolysis, proliferation, the cell cycle and metastasis of TC cells. Finally, we verified that artemisinin could target the degradation of HIF-1a and inhibit glycolysis in TC cells. Collectively, XIST levels in serum may be used as a tumor marker for TC promoted by HIF-1a, which could be treated using artemisinin.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0284242