Predictors and incidence of depression and anxiety in women undergoing infertility treatment: A cross-sectional study

• Published in: PloS one 2023-04, Vol.18 (4), p.e0284414-e0284414
• Main Authors: Wang, Lingyan, Tang, Youyin, Wang, Yuyang
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analysis; Anxiety; Anxiety - complications; Anxiety - diagnosis; Anxiety - epidemiology; Anxiety disorders; Anxiety Disorders - epidemiology; Biology and Life Sciences; Care and treatment; China - epidemiology; Coefficients; Consultants; Couples; Cross-Sectional Studies; Decision making; Depression - complications; Depression - diagnosis; Depression - epidemiology; Depression, Mental; Diagnosis; Evaluation; Factor analysis; Female; Generalized anxiety disorder; Glutamate decarboxylase; Health aspects; Health risks; Hospitals; Humans; Incidence; Infertility; Infertility, Female - complications; Infertility, Female - epidemiology; Infertility, Female - therapy; Mathematical analysis; Medical research; Medical treatment; Medically Unexplained Symptoms; Medicine and Health Sciences; Medicine, Experimental; Mental depression; Mental disorders; Mental illness; Multivariate analysis; Patient outcomes; Patients; Psychological aspects; Quality control; Questionnaires; Regression analysis; Reproducibility of Results; Reproductive technologies; Risk factors; Sleep; Sleep Initiation and Maintenance Disorders; Social Sciences; Software; Statistical analysis; Stress; Surveys; Validity; Women; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0284414

The global incidence of infertility is increasing year by year, and the association between infertility and mental illness has been widely concerned. The aim of this study was to investigate the incidence of anxiety and depression in infertile women in China and explore the risk factors which might lead to anxiety and depression. From January 2020 to December 2020, female infertile patients who received assisted reproduction technology (ART) treatment at West China Second Hospital were recruited and a total of 1712 eligible female patients were finally enrolled in this study. Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionaire-9 (PHQ-9) were used to evaluate the patients' psychological status. The reliability of all scales was evaluated by Cronbach's α and Spearman-Brown half coefficient, and Kaiser-Meyer-Olkin (KMO) value was calculated by factor analysis to evaluate validity. Univariate and multivariate logistic regression analysis were applied for assessing independent risk factors of anxiety and depression, respectively. The incidence of anxiety and depression in infertile women were 25.2% and 31.3%, respectively. Cronbach's α coefficients and Spearman-Brown half-fold coefficients of GAD-7 and PHQ-9 were 0.870, 0.825, 0.852 and 0.793, respectively. Univariate and multivariate logistic regression analysis showed that education level (junior college degree or above, OR:1. 6, 95% CI: 1.2-2.1, P = 0.003), somatic symptoms (severe somatic symptoms, OR:15.2, 95%CI: 5.6-41.3, P35) are prone to be complicated with depression symptoms.