Predictors and incidence of depression and anxiety in women undergoing infertility treatment: A cross-sectional study

The global incidence of infertility is increasing year by year, and the association between infertility and mental illness has been widely concerned. The aim of this study was to investigate the incidence of anxiety and depression in infertile women in China and explore the risk factors which might...

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Published in:PloS one 2023-04, Vol.18 (4), p.e0284414-e0284414
Main Authors: Wang, Lingyan, Tang, Youyin, Wang, Yuyang
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Anxiety
Anxiety - complications
Anxiety - diagnosis
Anxiety - epidemiology
Anxiety disorders
Anxiety Disorders - epidemiology
Biology and Life Sciences
Care and treatment
China - epidemiology
Coefficients
Consultants
Couples
Cross-Sectional Studies
Decision making
Depression - complications
Depression - diagnosis
Depression - epidemiology
Depression, Mental
Diagnosis
Evaluation
Factor analysis
Female
Generalized anxiety disorder
Glutamate decarboxylase
Health aspects
Health risks
Hospitals
Humans
Incidence
Infertility
Infertility, Female - complications
Infertility, Female - epidemiology
Infertility, Female - therapy
Mathematical analysis
Medical research
Medical treatment
Medically Unexplained Symptoms
Medicine and Health Sciences
Medicine, Experimental
Mental depression
Mental disorders
Mental illness
Multivariate analysis
Patient outcomes
Patients
Psychological aspects
Quality control
Questionnaires
Regression analysis
Reproducibility of Results
Reproductive technologies
Risk factors
Sleep
Sleep Initiation and Maintenance Disorders
Social Sciences
Software
Statistical analysis
Stress
Surveys
Validity
Women
Womens health
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creator Wang, Lingyan
Tang, Youyin
Wang, Yuyang
description The global incidence of infertility is increasing year by year, and the association between infertility and mental illness has been widely concerned. The aim of this study was to investigate the incidence of anxiety and depression in infertile women in China and explore the risk factors which might lead to anxiety and depression. From January 2020 to December 2020, female infertile patients who received assisted reproduction technology (ART) treatment at West China Second Hospital were recruited and a total of 1712 eligible female patients were finally enrolled in this study. Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionaire-9 (PHQ-9) were used to evaluate the patients' psychological status. The reliability of all scales was evaluated by Cronbach's α and Spearman-Brown half coefficient, and Kaiser-Meyer-Olkin (KMO) value was calculated by factor analysis to evaluate validity. Univariate and multivariate logistic regression analysis were applied for assessing independent risk factors of anxiety and depression, respectively. The incidence of anxiety and depression in infertile women were 25.2% and 31.3%, respectively. Cronbach's α coefficients and Spearman-Brown half-fold coefficients of GAD-7 and PHQ-9 were 0.870, 0.825, 0.852 and 0.793, respectively. Univariate and multivariate logistic regression analysis showed that education level (junior college degree or above, OR:1. 6, 95% CI: 1.2-2.1, P = 0.003), somatic symptoms (severe somatic symptoms, OR:15.2, 95%CI: 5.6-41.3, P35) are prone to be complicated with depression symptoms.
doi_str_mv 10.1371/journal.pone.0284414
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The aim of this study was to investigate the incidence of anxiety and depression in infertile women in China and explore the risk factors which might lead to anxiety and depression. From January 2020 to December 2020, female infertile patients who received assisted reproduction technology (ART) treatment at West China Second Hospital were recruited and a total of 1712 eligible female patients were finally enrolled in this study. Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionaire-9 (PHQ-9) were used to evaluate the patients' psychological status. The reliability of all scales was evaluated by Cronbach's α and Spearman-Brown half coefficient, and Kaiser-Meyer-Olkin (KMO) value was calculated by factor analysis to evaluate validity. Univariate and multivariate logistic regression analysis were applied for assessing independent risk factors of anxiety and depression, respectively. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lingyan</au><au>Tang, Youyin</au><au>Wang, Yuyang</au><au>Di Giuseppe, Jacopo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors and incidence of depression and anxiety in women undergoing infertility treatment: A cross-sectional study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-04-13</date><risdate>2023</risdate><volume>18</volume><issue>4</issue><spage>e0284414</spage><epage>e0284414</epage><pages>e0284414-e0284414</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The global incidence of infertility is increasing year by year, and the association between infertility and mental illness has been widely concerned. The aim of this study was to investigate the incidence of anxiety and depression in infertile women in China and explore the risk factors which might lead to anxiety and depression. From January 2020 to December 2020, female infertile patients who received assisted reproduction technology (ART) treatment at West China Second Hospital were recruited and a total of 1712 eligible female patients were finally enrolled in this study. Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionaire-9 (PHQ-9) were used to evaluate the patients' psychological status. The reliability of all scales was evaluated by Cronbach's α and Spearman-Brown half coefficient, and Kaiser-Meyer-Olkin (KMO) value was calculated by factor analysis to evaluate validity. Univariate and multivariate logistic regression analysis were applied for assessing independent risk factors of anxiety and depression, respectively. The incidence of anxiety and depression in infertile women were 25.2% and 31.3%, respectively. Cronbach's α coefficients and Spearman-Brown half-fold coefficients of GAD-7 and PHQ-9 were 0.870, 0.825, 0.852 and 0.793, respectively. Univariate and multivariate logistic regression analysis showed that education level (junior college degree or above, OR:1. 6, 95% CI: 1.2-2.1, P = 0.003), somatic symptoms (severe somatic symptoms, OR:15.2, 95%CI: 5.6-41.3, P&lt;0.001), sleep quality (poor sleep quality, OR:9.3, 95% CI:4.7-18.4, P&lt;0.001) were independent risk factors for anxiety. And age&gt;35 years old, moderate and severe somatic symptoms and poor sleep quality were independent risk factors for depression. Somatic symptoms and poor sleep quality are both the risk factors of anxiety and depression symptoms of infertile woman. And high educated (junior college degree or above) patients are more likely to be complicated with anxiety symptoms, while elderly patients (age&gt;35) are prone to be complicated with depression symptoms.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37053254</pmid><doi>10.1371/journal.pone.0284414</doi><tpages>e0284414</tpages><orcidid>https://orcid.org/0000-0001-8935-6668</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2023-04, Vol.18 (4), p.e0284414-e0284414
issn 1932-6203
1932-6203
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source Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central; Coronavirus Research Database
subjects Adult
Aged
Analysis
Anxiety
Anxiety - complications
Anxiety - diagnosis
Anxiety - epidemiology
Anxiety disorders
Anxiety Disorders - epidemiology
Biology and Life Sciences
Care and treatment
China - epidemiology
Coefficients
Consultants
Couples
Cross-Sectional Studies
Decision making
Depression - complications
Depression - diagnosis
Depression - epidemiology
Depression, Mental
Diagnosis
Evaluation
Factor analysis
Female
Generalized anxiety disorder
Glutamate decarboxylase
Health aspects
Health risks
Hospitals
Humans
Incidence
Infertility
Infertility, Female - complications
Infertility, Female - epidemiology
Infertility, Female - therapy
Mathematical analysis
Medical research
Medical treatment
Medically Unexplained Symptoms
Medicine and Health Sciences
Medicine, Experimental
Mental depression
Mental disorders
Mental illness
Multivariate analysis
Patient outcomes
Patients
Psychological aspects
Quality control
Questionnaires
Regression analysis
Reproducibility of Results
Reproductive technologies
Risk factors
Sleep
Sleep Initiation and Maintenance Disorders
Social Sciences
Software
Statistical analysis
Stress
Surveys
Validity
Women
Womens health
title Predictors and incidence of depression and anxiety in women undergoing infertility treatment: A cross-sectional study
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