Mycobacterium ulcerans culture results according to duration of prior antibiotic treatment: A cohort study

Mycobacterium ulcerans disease is a necrotising disease of the skin and subcutaneous tissue and is effectively treated with eight-weeks antibiotic therapy. Significant toxicities, however, are experienced under this prolonged regimen. Here, we investigated the length of antibiotic duration required...

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Bibliographic Details
Published in:PloS one 2023-04, Vol.18 (4), p.e0284201-e0284201
Main Authors: Tweedale, Brodie, Collier, Fiona, Waidyatillake, Nilakshi T, Athan, Eugene, O'Brien, Daniel P
Format: Article
Language:English
Subjects:
Analysis
Anti-Bacterial Agents - therapeutic use
Antibiotics
BCG
BCG vaccines
Biology and Life Sciences
Buruli ulcer
Buruli Ulcer - microbiology
Care and treatment
Ciprofloxacin
Clarithromycin
Cohort analysis
Cohort Studies
Complications and side effects
Diagnosis
Female
Humans
Laboratories
Lesions
Male
Medicine and Health Sciences
Middle Aged
Mycobacterium ulcerans
Patient outcomes
Patients
Regression analysis
Rifampin
Skin
Skin diseases
Surgery
Toxicity
Treatment Outcome
Ulcers
Variables
Citations: Items that this one cites
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Summary:Mycobacterium ulcerans disease is a necrotising disease of the skin and subcutaneous tissue and is effectively treated with eight-weeks antibiotic therapy. Significant toxicities, however, are experienced under this prolonged regimen. Here, we investigated the length of antibiotic duration required to achieve negative cultures of M. ulcerans disease lesions and evaluated the influence of patient characteristics on this outcome. M. ulcerans cases from an observational cohort that underwent antibiotic treatment prior to surgery and had post-excision culture assessment at Barwon Health, Victoria, from May 25 1998 to June 30 2019, were included. Antibiotic duration before surgery was grouped as
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0284201