Peripapillary choroidal microvasculature dropout is associated with poor prognosis in optic neuritis

To identify peripapillary choroidal microvasculature dropout (MvD) in eyes with optic neuritis and its association with longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses following diagnosis. A total of 48 eyes with optic neuritis was...

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Published in:PloS one 2023-04, Vol.18 (4), p.e0285017-e0285017
Main Authors: Lee, Jihei Sara, Park, Sungeun, Kim, Sung Sik, Kim, Chan Yun, Choi, Wungrak, Lee, Sang Yeop, Bae, Hyoung Won
Format: Article
Language:English
Subjects:
Analysis
Angiography
Antibodies
Automation
Biology and Life Sciences
Blood
Blood vessels
Care and treatment
Cataracts
Diabetic retinopathy
Disease
Eye
Eye movements
Glaucoma
Glycoproteins
Humans
Impairment
Magnetic resonance imaging
Medical imaging
Medical prognosis
Medicine and Health Sciences
Microvasculature
Microvessels - diagnostic imaging
Nerve Fibers
Nerves
Neuritis
Optic Disk - blood supply
Optic Disk - diagnostic imaging
Optic nerve
Optic neuritis
Optic Neuritis - diagnostic imaging
Optical Coherence Tomography
Optics
Patients
Prognosis
Quadrants
Research and Analysis Methods
Retina
Retinal Diseases
Retinal Ganglion Cells
Serology
Social Sciences
Thickness
Tomography
Tomography, Optical Coherence - methods
Visual Fields
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Summary:To identify peripapillary choroidal microvasculature dropout (MvD) in eyes with optic neuritis and its association with longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses following diagnosis. A total of 48 eyes with optic neuritis was evaluated to identify the presence of peripapillary choroidal MvD, defined as a focal capillary loss with no visible microvascular network in choroidal layer, using optical coherence tomography (OCT) angiography (OCTA). Patients were divided based on the presence of MvD. OCT and standard automated perimetry (SAP) conducted at 1, 3 and 6 months follow-up were analyzed. MvD was identified in 20 of 48 eyes (41.7%) with optic neuritis. MvD was most commonly found in the temporal quadrant (85.0%), and peripapillary retinal vessel density in the temporal quadrant was significantly lower in eyes with MvD (P = 0.012). At 6 months follow-up, optic neuritis eyes with MvD showed significantly thinner GCIP in superior, superotemporal, inferior and inferotemporal sectors (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0285017