Premature mortality and years of potential life lost from cardiovascular diseases: Protocol of a systematic review and meta-analysis

• Published in: PloS one 2023-05, Vol.18 (5), p.e0284052-e0284052
• Main Authors: Rodzlan Hasani, Wan Shakira, Muhamad, Nor Asiah, Maamor, Nur Hasnah, Hanis, Tengku Muhammad, Xin Wee, Chen, Abu Hassan, Muhammad Radzi, Abdul Karim, Zulkarnain, Musa, Kamarul Imran
• Format: Article
• Language: English
• Subjects: Age groups; Analysis; Availability; Biology and Life Sciences; Cardiovascular disease; Cardiovascular Diseases; Care and treatment; Clinical trials; Diabetes; Diagnosis; Estimates; Evaluation; Geographical locations; Health policy; Health risks; Heart diseases; Heterogeneity; Humans; Hypertension; Life Expectancy; Malaysia; Medicine and Health Sciences; Meta-analysis; Meta-Analysis as Topic; Mortality; Mortality, Premature; Observational studies; Online databases; Physical Sciences; Premature mortality; Public health; Research and Analysis Methods; Review Literature as Topic; Reviews; Risk factors; Study Protocol; Subgroups; Systematic review; Systematic Reviews as Topic
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0284052

Despite the burden of cardiovascular disease (CVD) continuing to increase globally, no comprehensive meta-analyses have been conducted quantifying premature CVD mortality. This paper reports the protocol for a systematic review and meta-analysis to derive updated estimates of premature CVD mortality. This review will include the studies that reported premature CVD mortality based on standard premature mortality indicators, including years of life lost (YLL), age standardized mortality rate (ASMR) or standardised mortality ratio (SMR). PUBMED, Scopus, Web of Science (WoS), CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) will be used as the literature databases. The study selection as well as the evaluation of the quality of the included articles will be done independently by two reviewers. Pooled estimates of YLL, ASMR, and SMR will be computed by applying random-effects meta-analysis. Heterogeneity among selected studies will be assessed using the I2 statistic and Q statistic with associated p-values. A funnel plot analysis and Egger's test will be conducted to assess the potential impact of publication bias. Depending on data availability, we propose to conduct subgroup analyses by sex, geographic location, main CVD types, and study time. Reporting of our findings will follow the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. Our meta-analysis will provide a comprehensive synthesis of the available evidence on premature CVD mortality, which is a major public health concern worldwide. The results of this meta-analysis will have important implications for clinical practice and public health policy, providing insights into strategies to prevent and manage premature CVD mortality. Systematic review registration: PROSPERO CRD42021288415. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288415.