Evaluation of a community health worker home visit intervention to improve child development in South Africa: A cluster-randomized controlled trial

• Published in: PLoS medicine 2023-04, Vol.20 (4), p.e1004222-e1004222
• Main Authors: Rockers, Peter C, Leppänen, Jukka M, Tarullo, Amanda, Coetzee, Lezanie, Fink, Günther, Hamer, Davidson H, Yousafzai, Aisha K, Evans, Denise
• Format: Article
• Language: English
• Subjects: Adolescent; Age; Analysis; Anthropometry; Biology and Life Sciences; Body height; Caregivers; Catchment areas; Child Development; Child, Preschool; Children; Children & youth; Childrens health; Clinical trials; Community health aides; Community Health Workers; COVID-19; Demography; Earth Sciences; EEG; Enrollments; Feasibility studies; Female; Growth Disorders; Health facilities; House Calls; Humans; Infant; Information processing; Intervention; Medical personnel; Medicine and Health Sciences; Motor skill; Pandemics; People and Places; Reaction time task; Research and Analysis Methods; Saccadic eye movements; Skills; Social Sciences; South Africa; Visual perception
• ISSN: 1549-1676; 1549-1277; 1549-1676
• DOI: 10.1371/journal.pmed.1004222

Effective integration of home visit interventions focused on early childhood development into existing service platforms is important for expanding access in low- and middle-income countries (LMICs). We designed and evaluated a home visit intervention integrated into community health worker (CHW) operations in South Africa. We conducted a cluster-randomized controlled trial in Limpopo Province, South Africa. CHWs operating in ward-based outreach teams (WBOTs; clusters) and caregiver-child dyads they served were randomized to the intervention or control group. Group assignment was masked from all data collectors. Dyads were eligible if they resided within a participating CHW catchment area, the caregiver was at least 18 years old, and the child was born after December 15, 2017. Intervention CHWs were trained on a job aid that included content on child health, nutrition, developmental milestones, and encouragement to engage in developmentally appropriate play-based activities, for use during regular monthly home visits with caregivers of children under 2 years of age. Control CHWs provided the local standard of care. Household surveys were administered to the full study sample at baseline and endline. Data were collected on household demographics and assets; caregiver engagement; and child diet, anthropometry, and development scores. In a subsample of children, electroencephalography (EEG) and eye-tracking measures of neural function were assessed at a lab concurrent with endline and at 2 interim time points. Primary outcomes were as follows: height-for-age z-scores (HAZs) and stunting; child development scores measured using the Malawi Developmental Assessment Tool (MDAT); EEG absolute gamma and total power; relative EEG gamma power; and saccadic reaction time (SRT)-an eye-tracking measure of visual processing speed. In the main analysis, unadjusted and adjusted impacts were estimated using intention-to-treat analysis. Adjusted models included a set of demographic covariates measured at baseline. On September 1, 2017, we randomly assigned 51 clusters to intervention (26 clusters, 607 caregiver-child dyads) or control (25 clusters, 488 caregiver-child dyads). At endline (last assessment June 11, 2021), 432 dyads (71%) in 26 clusters remained in the intervention group, and 332 dyads (68%) in 25 clusters remained in the control group. In total, 316 dyads attended the first lab visit, 316 dyads the second lab visit, and 284 dyads the third lab visit. In adjuste