Relationship of OCT-defined plaque characteristics with CCTA-derived coronary inflammation and CMR-derived global coronary flow reserve in patients with acute coronary syndrome

• Published in: PloS one 2023-05, Vol.18 (5), p.e0286196-e0286196
• Main Authors: Sugiyama, Tomoyo, Kanaji, Yoshihisa, Hoshino, Masahiro, Hada, Masahiro, Misawa, Toru, Nagamine, Tatsuhiro, Teng, Yun, Nogami, Kai, Ueno, Hiroki, Matsuda, Kazuki, Sayama, Kodai, Usui, Eisuke, Murai, Tadashi, Lee, Tetsumin, Yonetsu, Taishi, Sasano, Tetsuo, Kakuta, Tsunekazu
• Format: Article
• Language: English
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - diagnostic imaging; Acute coronary syndromes; Adipose tissue; Adipose tissues; Angiography; Attenuation; Biology and Life Sciences; Blood clots; Body fat; Cardiac patients; Care and treatment; Coherence (Optics); Computed tomography; Computed Tomography Angiography - methods; Coronary Angiography - methods; Coronary Artery Disease - diagnostic imaging; Coronary heart disease; Coronary vessels; Coronary Vessels - diagnostic imaging; CT imaging; Diagnosis; Evaluation; Humans; Hyperemia; Inflammation; Inflammation - diagnostic imaging; Lesions; Lipids; Magnetic resonance; Magnetic Resonance Imaging; Medical imaging; Medical research; Medicine and Health Sciences; Medicine, Experimental; Microvasculature; Optical Coherence Tomography; Patients; Percutaneous Coronary Intervention; Plaque, Atherosclerotic - diagnostic imaging; Research and Analysis Methods; Retrospective Studies; Software; Tomography; Tomography, Optical Coherence; Transluminal angioplasty; Veins & arteries
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0286196

The relationship of layered plaque detected by optical coherence tomography (OCT) with coronary inflammation and coronary flow reserve (CFR) remains elusive. We aimed to investigate the association of OCT-defined layered plaque with pericoronary adipose tissue (PCAT) inflammation assessed by coronary computed tomography angiography (CCTA) and global (G)-CFR assessed by cardiac magnetic resonance imaging (CMR) in patients with acute coronary syndrome (ACS). We retrospectively investigated 88 patients with first ACS who underwent preprocedural CCTA, OCT imaging of the culprit lesion prior to primary/urgent percutaneous coronary intervention (PCI), and postprocedural CMR. All patients were divided into two groups according to the presence and absence of OCT-defined layered plaque at the culprit lesion. Coronary inflammation was assessed by the mean value of PCAT attenuation (-190 to -30 HU) of the three major coronary vessels. G-CFR was obtained by quantifying absolute coronary sinus flow at rest and during maximum hyperemia. CCTA and CMR findings were compared between the groups. In a total of 88 patients, layered plaque was detected in 51 patients (58.0%). The patients with layered plaque had higher three-vessel-PCAT attenuation value (-68.58 ± 6.41 vs. -71.60 ± 5.21 HU, P = 0.021) and culprit vessel-PCAT attenuation value (-67.69 ± 7.76 vs. -72.07 ± 6.57 HU, P = 0.007) than those with non-layered plaque. The patients with layered plaque had lower G-CFR value (median, 2.26 [interquartile range, 1.78, 2.89] vs. 3.06 [2.41, 3.90], P = 0.003) than those with non-layered plaque. The presence of OCT-defined layered plaque at the culprit lesion was associated with high PCAT attenuation and low G-CFR after primary/urgent PCI in patients with ACS. OCT assessment of culprit plaque morphology and detection of layered plaque may help identify increased pericoronary inflammation and impaired CFR, potentially providing the risk stratification in patients with ACS and residual microvascular dysfunction after PCI.