Evaluation of tarsal injuries in C57BL/6J male mice

Tarsal joint abnormalities have been observed in aged male mice on a C57BL background. This joint disease consists of calcaneal displacement, inflammation, and proliferation of cartilage and connective tissue, that can progress to ankylosis of the joint. While tarsal pathology has been described pre...

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Bibliographic Details
Published in:PloS one 2023-06, Vol.18 (6), p.e0287204-e0287204
Main Authors: Kick, Brenda L, Anderson, Laura, Doty, Rosalinda, Wooley, Christine, Dyer, Meaghan, Green, Torrian, Knickerbocker, Veronica, Brown, Zoe, Loeber, Samantha, Wotton, Janine, Lyons, Bonnie, Waterman, Linda, Bichler, Zoë
Format: Article
Language:English
Subjects:
Abnormalities
Accreditation
Age
Animal experimentation
Animals
Ankylosis
Biology and Life Sciences
Body weight
Calcaneus
Care and treatment
Connective tissue diseases
Connective tissues
Diagnosis
Entrapment neuropathies
Evaluation
Females
Frailty
Histopathology
Inbreeding
Injuries
Joint diseases
Laboratory animals
Limbs
Male
Males
Medicine and Health Sciences
Mice
Mice, Inbred C57BL
Morphine
Motor Activity
Pain
Pain perception
Pilot projects
Research programs
Sensation
Social Sciences
Software
Tomography
Wheel running
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Description
Summary:Tarsal joint abnormalities have been observed in aged male mice on a C57BL background. This joint disease consists of calcaneal displacement, inflammation, and proliferation of cartilage and connective tissue, that can progress to ankylosis of the joint. While tarsal pathology has been described previously in C57BL/6N substrains, as well as in STR/ort and B10.BR strain, no current literature describes this disease occurring in C57BL/6J mice. More importantly the behavioral features that may result from such a change to the joint have yet to be evaluated. This condition was observed in older male mice of the C57BL/6J lineage, around the age of 20 weeks or older, at a frequency of 1% of the population. To assess potential phenotypic sequela, this study sought to evaluate body weight, frailty assessment, home cage wheel running, dynamic weight bearing, and mechanical allodynia with and without the presence of pain relief with morphine. Overall mice with tarsal injuries had significantly higher frailty scores (p< 0.05) and weighed less (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0287204