Expression of microRNAs and their target genes in melanomas originating from gynecologic sites

Melanomas from gynecologic sites (MOGS) are rare and have poor survival. MicroRNAs (miRs) regulate gene expression and are dysregulated in cancer. We hypothesized that MOGS would display unique miR and mRNA expression profiles. The miR and mRNA expression profile in RNA from formalin fixed, paraffin...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-06, Vol.18 (6), p.e0285804-e0285804
Main Authors: DiVincenzo, Mallory J, Angell, Colin D, Suarez-Kelly, Lorena P, Ren, Casey, Barricklow, Zoe, Moufawad, Maribelle, Fadda, Paolo, Yu, Lianbo, Backes, Floor J, Ring, Kari, Mills, Anne, Slingluff, Craig, Chung, Catherine, Gru, Alejandro A, Carson, 3rd, William E
Format: Article
Language:English
Subjects:
Analysis
Archives & records
Biology and life sciences
Cancer
Cervix
Clusters
Correlation
Diagnosis
Down-regulation
Female
Gene expression
Genes, cdc
Genetic aspects
Genital cancers
Humans
Immunotherapy
Kinases
Medicine and Health Sciences
Melanoma
Melanoma - genetics
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Mutation
Paraffin
Proteoglycans
Signal transduction
Skin cancer
Skin Neoplasms
SOCS-3 protein
Suppressor of Cytokine Signaling Proteins
Suppressors
TLR4 protein
Toll-like receptors
Tumor suppressor genes
Tumors
Vagina
Vulvar Neoplasms
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Melanomas from gynecologic sites (MOGS) are rare and have poor survival. MicroRNAs (miRs) regulate gene expression and are dysregulated in cancer. We hypothesized that MOGS would display unique miR and mRNA expression profiles. The miR and mRNA expression profile in RNA from formalin fixed, paraffin embedded vaginal melanomas (relative to vaginal mucosa) and vulvar melanomas (relative to cutaneous melanoma) were measured with the Nanostring Human miRNA assay and Tumor Signaling mRNA assay. Differential patterns of expression were identified for 21 miRs in vaginal and 47 miRs in vulvar melanoma (fold change >2, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0285804