Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution

To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototy...

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Bibliographic Details
Published in:PloS one 2023-06, Vol.18 (6), p.e0287783-e0287783
Main Authors: Bonnin, Sophie, Kubach, Sophie, Négrier, Pierre, Lewis, Warren, de Sisternes, Luis, Couturier, Aude, Erginay, Ali, Nassisi, Marco, Magazzeni, Stephanie, Lavia, Carlo, Tadayoni, Ramin
Format: Article
Language:English
Subjects:
Algorithms
Angiography
Biology and Life Sciences
Choroid - diagnostic imaging
Coherence (Optics)
Computer and Information Sciences
Correlation coefficient
Correlation coefficients
Density
Diagnosis
Engineering and Technology
Evaluation
Eye
Humans
Image quality
Medical examination
Medical imaging
Medicine and Health Sciences
Modules
Optical Coherence Tomography
Prospective Studies
Qualitative analysis
Research and Analysis Methods
Retina
Retina - diagnostic imaging
Retinal diseases
Software
Tomography
Tomography, Optical Coherence
Vascularization
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Summary:To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE. Qualitative analysis of superficial capillary plexus (SCP), deep capillary complex (DCC) retinal and CC angiograms were performed. Perfusion density (PD), vessel density (VD), and foveal avascular zone (FAZ) measurements were also compared. Qualitative analysis of single SCP and DCC retinal angiograms acquired with BE showed significantly better vessel sharpness (respectively, p = 0.0002, and p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0287783