Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution

To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototy...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-06, Vol.18 (6), p.e0287783-e0287783
Main Authors: Bonnin, Sophie, Kubach, Sophie, Négrier, Pierre, Lewis, Warren, de Sisternes, Luis, Couturier, Aude, Erginay, Ali, Nassisi, Marco, Magazzeni, Stephanie, Lavia, Carlo, Tadayoni, Ramin
Format: Article
Language:English
Subjects:
Algorithms
Angiography
Biology and Life Sciences
Coherence (Optics)
Computer and Information Sciences
Correlation coefficient
Correlation coefficients
Density
Diagnosis
Engineering and Technology
Evaluation
Eye
Image quality
Medical examination
Medical imaging
Medicine and Health Sciences
Modules
Optical Coherence Tomography
Qualitative analysis
Research and Analysis Methods
Retina
Retinal diseases
Software
Tomography
Vascularization
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c642t-a0f7f33c378888269f72885ead1dc0cf4b66f4fddc1057407e8cc824e93b72fe3
container_end_page e0287783
container_issue 6
container_start_page e0287783
container_title PloS one
container_volume 18
creator Bonnin, Sophie
Kubach, Sophie
Négrier, Pierre
Lewis, Warren
de Sisternes, Luis
Couturier, Aude
Erginay, Ali
Nassisi, Marco
Magazzeni, Stephanie
Lavia, Carlo
Tadayoni, Ramin
description To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE. Qualitative analysis of superficial capillary plexus (SCP), deep capillary complex (DCC) retinal and CC angiograms were performed. Perfusion density (PD), vessel density (VD), and foveal avascular zone (FAZ) measurements were also compared. Qualitative analysis of single SCP and DCC retinal angiograms acquired with BE showed significantly better vessel sharpness (respectively, p = 0.0002, and p
doi_str_mv 10.1371/journal.pone.0287783
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2831772768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A755350417</galeid><doaj_id>oai_doaj_org_article_642cb5f34e544d2693da0e60eb19a622</doaj_id><sourcerecordid>A755350417</sourcerecordid><originalsourceid>FETCH-LOGICAL-c642t-a0f7f33c378888269f72885ead1dc0cf4b66f4fddc1057407e8cc824e93b72fe3</originalsourceid><addsrcrecordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWHJM5eoarisFKlSuVwaznOOHGV2MFOELwMz4rTTaoN6gXJRZzx9_8ejz1J8pzgLWGcvLtxo7ey3fbOwhbTgvOCPUhOyY7RTU4xe3g0PkmehHCDccaKPH-cnDDOdvEPnyZ_rmEw0QYp2Zu2lf43krZCqnHeuCVmApIhQAgd2AGNwdgaSVSC7FDnKqMNeOT6wajJxzXgwSpAg-tc7WXfTJa1WcZRMbbTLDJWeZABUCsH8FG7eHgIrh0H4-zT5JGWbYBn8_cs-fbxw9eLz5vLq0_7i_PLjcpTOmwk1lwzphgv4kPznea0KDKQFakUVjot81ynuqoUwRlPMYdCqYKmsGMlpxrYWfLy4Nu3Loi5tEHQghHOKc-LSOwPROXkjei96WKthJNG3Aacr4X0Mf0WRExJlZlmKWRpWsVsWCUx5BhKspM5pdHr_bzaWHZQqVjVuP2V6XrGmkbU7qcgmBGGsymbN7ODdz9GCIPoTFAQD8uCG28TpxmnjEzoq3_Q-7c3U7WMOzBWu7iwmkzFOc8yluGU8Eht76HiW0FnVLyI2sT4SvB2JYjMAL-GWo4hiP2X6_9nr76v2ddHbAOyHZrlzoQ1mB5A5V0IHvRdlQkWUx8t1RBTH4m5j6LsxfEJ3YmWxmF_AVCQHEI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2831772768</pqid></control><display><type>article</type><title>Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution</title><source>PubMed Central (Open Access)</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><creator>Bonnin, Sophie ; Kubach, Sophie ; Négrier, Pierre ; Lewis, Warren ; de Sisternes, Luis ; Couturier, Aude ; Erginay, Ali ; Nassisi, Marco ; Magazzeni, Stephanie ; Lavia, Carlo ; Tadayoni, Ramin</creator><contributor>Fawzi, Amani A.</contributor><creatorcontrib>Bonnin, Sophie ; Kubach, Sophie ; Négrier, Pierre ; Lewis, Warren ; de Sisternes, Luis ; Couturier, Aude ; Erginay, Ali ; Nassisi, Marco ; Magazzeni, Stephanie ; Lavia, Carlo ; Tadayoni, Ramin ; Fawzi, Amani A.</creatorcontrib><description>To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE. Qualitative analysis of superficial capillary plexus (SCP), deep capillary complex (DCC) retinal and CC angiograms were performed. Perfusion density (PD), vessel density (VD), and foveal avascular zone (FAZ) measurements were also compared. Qualitative analysis of single SCP and DCC retinal angiograms acquired with BE showed significantly better vessel sharpness (respectively, p = 0.0002, and p&lt;0.0001), and greater peripheral image quality (p = 0.028 and p = 0.007) compared to standard OCTA images. Mean VD of whole retina single scans was significantly higher for BE angiograms compared to classic angiograms (28.16 ±1.29 mm-1 and 23.36 ±0.92 mm-1, respectively, p&lt;0.0001). Repeatability of VD, PD and FAZ raw size were found to be similar between the two methods (intraclass correlation coefficient: 0.671, 0.604 and 0.994 with BE versus 0.764, 0.638 and 0.990 without BE). CC image quality was found to be significantly superior with BE, and flow deficits were more visible in all BE scans compared to standard scans. An increase in lateral resolution of the OCT beam resulted in higher quality of retinal and choriocapillaris OCTA images in healthy subjects. These results provide significant insights into the future OCTA imaging enhancements.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0287783</identifier><identifier>PMID: 37390050</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Algorithms ; Angiography ; Biology and Life Sciences ; Coherence (Optics) ; Computer and Information Sciences ; Correlation coefficient ; Correlation coefficients ; Density ; Diagnosis ; Engineering and Technology ; Evaluation ; Eye ; Image quality ; Medical examination ; Medical imaging ; Medicine and Health Sciences ; Modules ; Optical Coherence Tomography ; Qualitative analysis ; Research and Analysis Methods ; Retina ; Retinal diseases ; Software ; Tomography ; Vascularization</subject><ispartof>PloS one, 2023-06, Vol.18 (6), p.e0287783-e0287783</ispartof><rights>Copyright: © 2023 Bonnin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2023 Public Library of Science</rights><rights>2023 Bonnin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Bonnin et al 2023 Bonnin et al</rights><rights>2023 Bonnin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c642t-a0f7f33c378888269f72885ead1dc0cf4b66f4fddc1057407e8cc824e93b72fe3</cites><orcidid>0000-0003-2614-9412 ; 0000-0001-8549-7455</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2831772768/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2831772768?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,37011,44588,53789,53791,74896</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37390050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fawzi, Amani A.</contributor><creatorcontrib>Bonnin, Sophie</creatorcontrib><creatorcontrib>Kubach, Sophie</creatorcontrib><creatorcontrib>Négrier, Pierre</creatorcontrib><creatorcontrib>Lewis, Warren</creatorcontrib><creatorcontrib>de Sisternes, Luis</creatorcontrib><creatorcontrib>Couturier, Aude</creatorcontrib><creatorcontrib>Erginay, Ali</creatorcontrib><creatorcontrib>Nassisi, Marco</creatorcontrib><creatorcontrib>Magazzeni, Stephanie</creatorcontrib><creatorcontrib>Lavia, Carlo</creatorcontrib><creatorcontrib>Tadayoni, Ramin</creatorcontrib><title>Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE. Qualitative analysis of superficial capillary plexus (SCP), deep capillary complex (DCC) retinal and CC angiograms were performed. Perfusion density (PD), vessel density (VD), and foveal avascular zone (FAZ) measurements were also compared. Qualitative analysis of single SCP and DCC retinal angiograms acquired with BE showed significantly better vessel sharpness (respectively, p = 0.0002, and p&lt;0.0001), and greater peripheral image quality (p = 0.028 and p = 0.007) compared to standard OCTA images. Mean VD of whole retina single scans was significantly higher for BE angiograms compared to classic angiograms (28.16 ±1.29 mm-1 and 23.36 ±0.92 mm-1, respectively, p&lt;0.0001). Repeatability of VD, PD and FAZ raw size were found to be similar between the two methods (intraclass correlation coefficient: 0.671, 0.604 and 0.994 with BE versus 0.764, 0.638 and 0.990 without BE). CC image quality was found to be significantly superior with BE, and flow deficits were more visible in all BE scans compared to standard scans. An increase in lateral resolution of the OCT beam resulted in higher quality of retinal and choriocapillaris OCTA images in healthy subjects. These results provide significant insights into the future OCTA imaging enhancements.</description><subject>Algorithms</subject><subject>Angiography</subject><subject>Biology and Life Sciences</subject><subject>Coherence (Optics)</subject><subject>Computer and Information Sciences</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Density</subject><subject>Diagnosis</subject><subject>Engineering and Technology</subject><subject>Evaluation</subject><subject>Eye</subject><subject>Image quality</subject><subject>Medical examination</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Modules</subject><subject>Optical Coherence Tomography</subject><subject>Qualitative analysis</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retinal diseases</subject><subject>Software</subject><subject>Tomography</subject><subject>Vascularization</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MWHJM5eoarisFKlSuVwaznOOHGV2MFOELwMz4rTTaoN6gXJRZzx9_8ejz1J8pzgLWGcvLtxo7ey3fbOwhbTgvOCPUhOyY7RTU4xe3g0PkmehHCDccaKPH-cnDDOdvEPnyZ_rmEw0QYp2Zu2lf43krZCqnHeuCVmApIhQAgd2AGNwdgaSVSC7FDnKqMNeOT6wajJxzXgwSpAg-tc7WXfTJa1WcZRMbbTLDJWeZABUCsH8FG7eHgIrh0H4-zT5JGWbYBn8_cs-fbxw9eLz5vLq0_7i_PLjcpTOmwk1lwzphgv4kPznea0KDKQFakUVjot81ynuqoUwRlPMYdCqYKmsGMlpxrYWfLy4Nu3Loi5tEHQghHOKc-LSOwPROXkjei96WKthJNG3Aacr4X0Mf0WRExJlZlmKWRpWsVsWCUx5BhKspM5pdHr_bzaWHZQqVjVuP2V6XrGmkbU7qcgmBGGsymbN7ODdz9GCIPoTFAQD8uCG28TpxmnjEzoq3_Q-7c3U7WMOzBWu7iwmkzFOc8yluGU8Eht76HiW0FnVLyI2sT4SvB2JYjMAL-GWo4hiP2X6_9nr76v2ddHbAOyHZrlzoQ1mB5A5V0IHvRdlQkWUx8t1RBTH4m5j6LsxfEJ3YmWxmF_AVCQHEI</recordid><startdate>20230630</startdate><enddate>20230630</enddate><creator>Bonnin, Sophie</creator><creator>Kubach, Sophie</creator><creator>Négrier, Pierre</creator><creator>Lewis, Warren</creator><creator>de Sisternes, Luis</creator><creator>Couturier, Aude</creator><creator>Erginay, Ali</creator><creator>Nassisi, Marco</creator><creator>Magazzeni, Stephanie</creator><creator>Lavia, Carlo</creator><creator>Tadayoni, Ramin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2614-9412</orcidid><orcidid>https://orcid.org/0000-0001-8549-7455</orcidid></search><sort><creationdate>20230630</creationdate><title>Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution</title><author>Bonnin, Sophie ; Kubach, Sophie ; Négrier, Pierre ; Lewis, Warren ; de Sisternes, Luis ; Couturier, Aude ; Erginay, Ali ; Nassisi, Marco ; Magazzeni, Stephanie ; Lavia, Carlo ; Tadayoni, Ramin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c642t-a0f7f33c378888269f72885ead1dc0cf4b66f4fddc1057407e8cc824e93b72fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algorithms</topic><topic>Angiography</topic><topic>Biology and Life Sciences</topic><topic>Coherence (Optics)</topic><topic>Computer and Information Sciences</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Density</topic><topic>Diagnosis</topic><topic>Engineering and Technology</topic><topic>Evaluation</topic><topic>Eye</topic><topic>Image quality</topic><topic>Medical examination</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Modules</topic><topic>Optical Coherence Tomography</topic><topic>Qualitative analysis</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Retinal diseases</topic><topic>Software</topic><topic>Tomography</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonnin, Sophie</creatorcontrib><creatorcontrib>Kubach, Sophie</creatorcontrib><creatorcontrib>Négrier, Pierre</creatorcontrib><creatorcontrib>Lewis, Warren</creatorcontrib><creatorcontrib>de Sisternes, Luis</creatorcontrib><creatorcontrib>Couturier, Aude</creatorcontrib><creatorcontrib>Erginay, Ali</creatorcontrib><creatorcontrib>Nassisi, Marco</creatorcontrib><creatorcontrib>Magazzeni, Stephanie</creatorcontrib><creatorcontrib>Lavia, Carlo</creatorcontrib><creatorcontrib>Tadayoni, Ramin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonnin, Sophie</au><au>Kubach, Sophie</au><au>Négrier, Pierre</au><au>Lewis, Warren</au><au>de Sisternes, Luis</au><au>Couturier, Aude</au><au>Erginay, Ali</au><au>Nassisi, Marco</au><au>Magazzeni, Stephanie</au><au>Lavia, Carlo</au><au>Tadayoni, Ramin</au><au>Fawzi, Amani A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2023-06-30</date><risdate>2023</risdate><volume>18</volume><issue>6</issue><spage>e0287783</spage><epage>e0287783</epage><pages>e0287783-e0287783</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named "Beam expander" (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE. Qualitative analysis of superficial capillary plexus (SCP), deep capillary complex (DCC) retinal and CC angiograms were performed. Perfusion density (PD), vessel density (VD), and foveal avascular zone (FAZ) measurements were also compared. Qualitative analysis of single SCP and DCC retinal angiograms acquired with BE showed significantly better vessel sharpness (respectively, p = 0.0002, and p&lt;0.0001), and greater peripheral image quality (p = 0.028 and p = 0.007) compared to standard OCTA images. Mean VD of whole retina single scans was significantly higher for BE angiograms compared to classic angiograms (28.16 ±1.29 mm-1 and 23.36 ±0.92 mm-1, respectively, p&lt;0.0001). Repeatability of VD, PD and FAZ raw size were found to be similar between the two methods (intraclass correlation coefficient: 0.671, 0.604 and 0.994 with BE versus 0.764, 0.638 and 0.990 without BE). CC image quality was found to be significantly superior with BE, and flow deficits were more visible in all BE scans compared to standard scans. An increase in lateral resolution of the OCT beam resulted in higher quality of retinal and choriocapillaris OCTA images in healthy subjects. These results provide significant insights into the future OCTA imaging enhancements.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>37390050</pmid><doi>10.1371/journal.pone.0287783</doi><tpages>e0287783</tpages><orcidid>https://orcid.org/0000-0003-2614-9412</orcidid><orcidid>https://orcid.org/0000-0001-8549-7455</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2023-06, Vol.18 (6), p.e0287783-e0287783
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2831772768
source PubMed Central (Open Access); Publicly Available Content Database (Proquest) (PQ_SDU_P3)
subjects Algorithms
Angiography
Biology and Life Sciences
Coherence (Optics)
Computer and Information Sciences
Correlation coefficient
Correlation coefficients
Density
Diagnosis
Engineering and Technology
Evaluation
Eye
Image quality
Medical examination
Medical imaging
Medicine and Health Sciences
Modules
Optical Coherence Tomography
Qualitative analysis
Research and Analysis Methods
Retina
Retinal diseases
Software
Tomography
Vascularization
title Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T10%3A25%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinal%20capillary%20and%20choriocapillaris%20assessment%20using%20a%20beam%20modifier%20optical%20coherence%20tomography%20angiography%20module%20to%20increase%20lateral%20optical%20resolution&rft.jtitle=PloS%20one&rft.au=Bonnin,%20Sophie&rft.date=2023-06-30&rft.volume=18&rft.issue=6&rft.spage=e0287783&rft.epage=e0287783&rft.pages=e0287783-e0287783&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0287783&rft_dat=%3Cgale_plos_%3EA755350417%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c642t-a0f7f33c378888269f72885ead1dc0cf4b66f4fddc1057407e8cc824e93b72fe3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2831772768&rft_id=info:pmid/37390050&rft_galeid=A755350417&rfr_iscdi=true