Prognostic value of RGS1 and mTOR Immunohistochemical expression in Egyptian multiple myeloma patients; A single center study

Prognostic factors in plasma cell myeloma were proved to be related to signaling pathways and associated transcription factors. RGS1 and mTOR were known to play an important role in the pathogenesis of multiple myeloma. The aim of the study was to evaluate the expression and the prognostic value of...

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Bibliographic Details
Published in:PloS one 2023-07, Vol.18 (7), p.e0288357-e0288357
Main Authors: Hafez, Nora, Refaat, Lobna, ElGebaly, Omnia K, Elhariry, Hossam M, Ghareeb, Mohammed, Fathalla, Lamiaa A
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
B cells
Biology and Life Sciences
Biopsy
Bone marrow
Cancer
Care and treatment
Cell cycle
Clinical trials
Criteria
DNA binding proteins
Egypt
Evaluation
Female
Gene amplification
Gene expression
Hematology
Humans
Immunohistochemistry
Insulin
Insulin-like growth factors
Kidney cancer
Kinases
Lymphoma
Male
Medical prognosis
Medical research
Medicine and Health Sciences
Medicine, Experimental
Middle Aged
Multiple myeloma
Multiple Myeloma - diagnosis
Pathogenesis
Patients
Physical Sciences
Plasma
Prognosis
Proteins
Research and Analysis Methods
RGS Proteins - genetics
Signal transduction
Statistical analysis
Survival
TOR protein
TOR Serine-Threonine Kinases
Transcription factors
Type 2 diabetes
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Summary:Prognostic factors in plasma cell myeloma were proved to be related to signaling pathways and associated transcription factors. RGS1 and mTOR were known to play an important role in the pathogenesis of multiple myeloma. The aim of the study was to evaluate the expression and the prognostic value of RGS1 and mTOR and their relation to clinical as well as other diagnostic criteria in multiple myeloma. The present study included 44 denovo Myeloma patients, recruited from the Medical Oncology Department, National Cancer Institute, Cairo University. Detection of RGS1 and mTOR expression was performed using Immunohistochemical staining on bone marrow biopsy sections. The median age was 51 years with male to female ratio 1.58:1. There was a positive highly statistically significant correlation between RGS1 and mTOR among all studied cases (p value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0288357