Global long-term trends and spatial cluster analysis of pancreatic cancer incidence and mortality over a 30-year period using the global burden of disease study 2019 data

• Published in: PloS one 2023-07, Vol.18 (7), p.e0288755-e0288755
• Main Authors: Amini, Maedeh, Azizmohammad Looha, Mehdi, Rahimi Pordanjani, Sajjad, Asadzadeh Aghdaei, Hamid, Pourhoseingholi, Mohamad Amin
• Format: Article
• Language: English
• Subjects: Biology and Life Sciences; Cancer; Care and treatment; Cluster Analysis; Clustering; Diagnosis; Disease hot spots; Earth Sciences; Evaluation; Fatalities; Female; Geographical variations; Global Burden of Disease; Global Health; Humans; Incidence; Male; Malignancy; Medicine and Health Sciences; Mortality; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - epidemiology; People and Places; Public health; Regression analysis; Sex differences; Spatial Analysis; Spatial distribution; Trends
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0288755

Pancreatic cancer (PC) is one of the most fatal malignancies, and its incidence and mortality rates are growing annually throughout the world. In this research, we aimed to investigate the time trends and identify the spatial clusters of incidence and mortality on a global scale over the last 30 years, using the Global Burden of Disease (GBD) study 2019 data. Age-standardized incidence and mortality data due to PC were extracted from the GBD study, which was carried out from 1990 to 2019. A Joinpoint regression analysis was utilized to examine trends in the incidence and mortality of PC over the past three decades. As such, spatial analyses were undertaken to detect the spatial distribution and clustering of the metrics globally. It was observed that both the incidence and mortality rates were higher in males than in females worldwide. The global mortality and incidence rates significantly increased by 0.8% per year over the time of follow-up period (p