NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.

Saved in:
Bibliographic Details
Published in:PLoS biology 2023-07, Vol.21 (7), p.e3002226-e3002226
Main Author: Yao, Yao
Format: Article
Language:English
Subjects:
Analysis
Atherosclerosis
Biology and Life Sciences
Brain
Cytokines
Cytoplasm
Disease
Hypotheses
Identification and classification
Inflammation
Ischemia
Medicine and Health Sciences
Messenger RNA
Microglia
Morphology
Primer
Properties
Research and Analysis Methods
Stroke (Disease)
Transcription factors
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002226