Caregivers’ use of herbal and conventional medicine to treat children with sickle cell disease at Jinja Regional Referral Hospital, Eastern Uganda: A cross-sectional study

• Published in: PloS one 2023-09, Vol.18 (9), p.e0291008-e0291008
• Main Authors: Apolot, Consiliate, Obakiro, Samuel Baker, Mukunya, David, Olupot-Olupot, Peter, Matovu, Joseph K. B
• Format: Article
• Language: English
• Subjects: Alternative medicine; Analysis; Biology and Life Sciences; Care and treatment; Caregivers; Children; Children & youth; Chronic illnesses; Communicative disorders in children; Complications and side effects; Cross-sectional studies; Disease management; Diseases; Drugs; Education; Health facilities; Health promotion; Herbal medicine; Hospitals; Medical screening; Medicine; Medicine and Health Sciences; Medicine, Botanic; Medicine, Herbal; Patient outcomes; People and Places; Questionnaires; Regression models; Sickle cell anemia; Sickle cell anemia in children; Sickle cell disease; Social Sciences; Sorghum; Theory of planned behavior
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0291008

Evidence suggests use of herbal and conventional medicines in the treatment of Sickle Cell Disease (SCD). We examined factors associated with caregivers' use of combined herbal and conventional medicine to treat children with SCD. A cross-sectional study was conducted at Jinja Regional Referral Hospital between January and March 2022. Caregivers of children with SCD aged 1 to 18 years attending the Sickle Cell Clinic were interviewed using structured questionnaires. We collected data on caregivers' socio-demographic characteristics, perceptions of and intentions to use either or both therapies, self-reported use of either or both therapies and community and health-related factors. A multivariable logistic regression model was computed to assess the factors independently associated with caregivers' use of combined therapy, using Stata version 15.0. 372 caregivers were interviewed. On average, respondents were aged 34.3 years (Standard Deviation [SD]: ±9.8 years). 37% (n = 138) of the caregivers reported the use of both herbal and conventional medicine, 58.3% (n = 217) reported use of only conventional medicine, while 4.6% (n = 17) reported use of herbal medicine only. Higher odds of using combination therapy were found in caregivers aged 60+ years (adjusted odds ratio [AOR] = 11.8; 95% CI: 1.2, 115.2), those with lower secondary education (AOR = 6.2; 95% CI: 1.5, 26.0), those who believed in the safety of herbal medicine (AOR = 3.3; 95% CI: 1.5, 7.6) and those who thought that use of both therapies were safe (AOR = 7.7; 95% CI: 3.5, 17.0). More than one-third of the caregivers reported use of combined herbal and conventional medicine, most of whom were older (>60%) and had lower secondary education. There is need for targeted health promotion to educate caregivers about the dangers of using both herbal and conventional medicines in treating children with SCD.