Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics

• Published in: PLoS pathogens 2023-08, Vol.19 (8), p.e1011588-e1011588
• Main Authors: Hollingsworth, Brandon D, Grubaugh, Nathan D, Lazzaro, Brian P, Murdock, Courtney C
• Format: Article
• Language: English
• Subjects: Analysis; Analytical methods; Animals; Biology and Life Sciences; Computer and Information Sciences; Control; Control programs; Costs; Dengue fever; Development and progression; Disease control; Disease transmission; Dispersal; Earth Sciences; Ecology; Ecology and Environmental Sciences; Epidemiology; Genetic aspects; Genetic diversity; Genetic Vectors; Genomics; Infections; Insect control; Insect Viruses; Insecta; Insects; Medicine and Health Sciences; Mosquitoes; Pathogens; Phylogeny; Population genetics; Population structure; Population studies; Populations; Prevalence studies (Epidemiology); Public health; Review; Vector-borne diseases; Viruses
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1011588

Several aspects of mosquito ecology that are important for vectored disease transmission and control have been difficult to measure at epidemiologically important scales in the field. In particular, the ability to describe mosquito population structure and movement rates has been hindered by difficulty in quantifying fine-scale genetic variation among populations. The mosquito virome represents a possible avenue for quantifying population structure and movement rates across multiple spatial scales. Mosquito viromes contain a diversity of viruses, including several insect-specific viruses (ISVs) and "core" viruses that have high prevalence across populations. To date, virome studies have focused on viral discovery and have only recently begun examining viral ecology. While nonpathogenic ISVs may be of little public health relevance themselves, they provide a possible route for quantifying mosquito population structure and dynamics. For example, vertically transmitted viruses could behave as a rapidly evolving extension of the host's genome. It should be possible to apply established analytical methods to appropriate viral phylogenies and incidence data to generate novel approaches for estimating mosquito population structure and dispersal over epidemiologically relevant timescales. By studying the virome through the lens of spatial and genomic epidemiology, it may be possible to investigate otherwise cryptic aspects of mosquito ecology. A better understanding of mosquito population structure and dynamics are key for understanding mosquito-borne disease ecology and methods based on ISVs could provide a powerful tool for informing mosquito control programs.