Collaborative nowcasting of COVID-19 hospitalization incidences in Germany

• Published in: PLoS computational biology 2023-08, Vol.19 (8), p.e1011394-e1011394
• Main Authors: Wolffram, Daniel, Abbott, Sam, An der Heiden, Matthias, Funk, Sebastian, Günther, Felix, Hailer, Davide, Heyder, Stefan, Hotz, Thomas, van de Kassteele, Jan, Küchenhoff, Helmut, Müller-Hansen, Sören, Syliqi, Diellë, Ullrich, Alexander, Weigert, Maximilian, Schienle, Melanie, Bracher, Johannes
• Format: Article
• Language: English
• Subjects: Bias; Case reports; Collaboration; COVID-19; Epidemics; Epidemiology; Forecasts and trends; Germany; Hospital care; Hospitalization; Infectious diseases; Information management; Mean; Medicine and Health Sciences; Methods; Outbreaks; Pandemics; People and Places; Public health; Quantiles; Real time; Sentinel health events; Situational awareness; Statistical analysis; Statistics; Teams; Trends; Viral diseases
• ISSN: 1553-7358; 1553-734X; 1553-7358
• DOI: 10.1371/journal.pcbi.1011394

Real-time surveillance is a crucial element in the response to infectious disease outbreaks. However, the interpretation of incidence data is often hampered by delays occurring at various stages of data gathering and reporting. As a result, recent values are biased downward, which obscures current trends. Statistical nowcasting techniques can be employed to correct these biases, allowing for accurate characterization of recent developments and thus enhancing situational awareness. In this paper, we present a preregistered real-time assessment of eight nowcasting approaches, applied by independent research teams to German 7-day hospitalization incidences during the COVID-19 pandemic. This indicator played an important role in the management of the outbreak in Germany and was linked to levels of non-pharmaceutical interventions via certain thresholds. Due to its definition, in which hospitalization counts are aggregated by the date of case report rather than admission, German hospitalization incidences are particularly affected by delays and can take several weeks or months to fully stabilize. For this study, all methods were applied from 22 November 2021 to 29 April 2022, with probabilistic nowcasts produced each day for the current and 28 preceding days. Nowcasts at the national, state, and age-group levels were collected in the form of quantiles in a public repository and displayed in a dashboard. Moreover, a mean and a median ensemble nowcast were generated. We find that overall, the compared methods were able to remove a large part of the biases introduced by delays. Most participating teams underestimated the importance of very long delays, though, resulting in nowcasts with a slight downward bias. The accompanying prediction intervals were also too narrow for almost all methods. Averaged over all nowcast horizons, the best performance was achieved by a model using case incidences as a covariate and taking into account longer delays than the other approaches. For the most recent days, which are often considered the most relevant in practice, a mean ensemble of the submitted nowcasts performed best. We conclude by providing some lessons learned on the definition of nowcasting targets and practical challenges.