Drosophila melanogaster as a model for studies related to the toxicity of lavender, ginger and copaiba essential oils

This study addresses the current trend of essential oils in alternative medicine using the non-chordate model Drosophila melanogaster. Following the three R's principles, it proposes non-chordate models to fill knowledge gaps on essential oil toxicity. Copaiba, lavender, and ginger essential oi...

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Bibliographic Details
Published in:PloS one 2023-09, Vol.18 (9), p.e0291242-e0291242
Main Authors: Bernardes, Lucas Matos Martins, Malta, Serena Mares, Rodrigues, Tamiris Sabrina, Covizzi, Luiz Fernando, Rosa, Rafael Borges, Justino, Allisson Benatti, Teixeira, Renata Roland, Espíndola, Foued Salmen, Oliveira Dos Santos, Débora, Vieira, Carlos Ueira, Vieira da Silva, Murilo
Format: Article
Language:English
Subjects:
Alternative medicine
Analysis
Animals
Anti-inflammatory agents
Biology and Life Sciences
Brain
Chordata
Climbing
Drosophila
Drosophila melanogaster
Drug discovery
Drug dosages
Essences and essential oils
Essential oils
Food
Fruit flies
Genes
Genomes
Ginger
Health aspects
Inflammation
Insects
Laboratory animals
Lavandula - chemistry
Lavender oil
Life span
Medicine and Health Sciences
Modelling
Oils & fats
Oils, Volatile - chemistry
Oils, Volatile - toxicity
Plant Oils - chemistry
Plant Oils - toxicity
Properties
Research and Analysis Methods
Toxicity
Zingiber officinale - chemistry
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Summary:This study addresses the current trend of essential oils in alternative medicine using the non-chordate model Drosophila melanogaster. Following the three R's principles, it proposes non-chordate models to fill knowledge gaps on essential oil toxicity. Copaiba, lavender, and ginger essential oils are evaluated for effects on D. melanogaster lifespan, climbing ability, and brain structure, while their anti-inflammatory properties are also analyzed. Results show dose-related differences: higher concentrations (0.25% v/v) cause brain deterioration and impaired climbing, while lower concentrations (0.0625% v/v for copaiba and ginger; 0.125% for lavender) have no effect on climbing or brain structure. Lavender oil significantly extends lifespan and maintains anti-inflammatory activity when ingested, underscoring its therapeutic potential. These findings highlight the importance of D. melanogaster as a model for studying essential oil properties, potentially replacing chordate models. In addition, this research advances alternative remedies for currently incurable diseases, with lavender oil emerging as a promising candidate for drug discovery.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0291242