A tale of 2 gasses, 1 regulator, and cholesterol homeostasis

There is a burgeoning appreciation for the wide-ranging effects of carbon dioxide on transcriptional regulation and metabolism. Here, Bolshette and colleagues provide the first link between carbon dioxide and the master transcriptional regulator of cholesterol homeostasis.

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Bibliographic Details
Published in:PLoS biology 2023-11, Vol.21 (11), p.e3002401-e3002401
Main Authors: Fenton, Nicole M, Brown, Andrew J
Format: Article
Language:English
Subjects:
Analysis
Biosynthesis
Carbon dioxide
Cholesterol
Core curriculum
Endoplasmic reticulum
Gene regulation
Homeostasis
Membranes
Metabolism
Physiology
Protein binding
Sterols
Waste products
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Description
Summary:There is a burgeoning appreciation for the wide-ranging effects of carbon dioxide on transcriptional regulation and metabolism. Here, Bolshette and colleagues provide the first link between carbon dioxide and the master transcriptional regulator of cholesterol homeostasis.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002401