Degrade to stay healthy-Proteolytic interplay during inflammation

Proteasomes and autophagy constitute the 2 main proteolytic machineries for cytoplasmic content. A new study in PLOS Biology now demonstrates that autophagy stimulation alters proteasome composition, degrading hyperactive immunoproteasomes and thereby limiting inflammation.

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Bibliographic Details
Published in:PLoS biology 2024-03, Vol.22 (3), p.e3002548-e3002548
Main Author: Münz, Christian
Format: Article
Language:English
Subjects:
Analysis
Antigens
Autophagy
Biology and Life Sciences
Dendritic cells
Humans
Identification and classification
Inflammation
Inflammatory bowel disease
Inflammatory diseases
Macrophages - metabolism
Medical research
Medicine and Health Sciences
Peptides
Primer
Proteases
Proteasome Endopeptidase Complex - metabolism
Proteasomes
Proteins
Proteolysis
Citations: Items that this one cites
Online Access:Get full text
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Description
Summary:Proteasomes and autophagy constitute the 2 main proteolytic machineries for cytoplasmic content. A new study in PLOS Biology now demonstrates that autophagy stimulation alters proteasome composition, degrading hyperactive immunoproteasomes and thereby limiting inflammation.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002548