Associations between soil-transmitted helminth infections and physical activity, physical fitness, and cardiovascular disease risk in primary schoolchildren from Gqeberha, South Africa

• Published in: PLoS neglected tropical diseases 2023-10, Vol.17 (10), p.e0011664-e0011664
• Main Authors: Nqweniso, Siphesihle, Walter, Cheryl, du Randt, Rosa, Adams, Larissa, Beckmann, Johanna, Coulibaly, Jean T, Dolley, Danielle, Joubert, Nandi, Long, Kurt Z, Müller, Ivan, Nienaber, Madeleine, Pühse, Uwe, Seelig, Harald, Steinmann, Peter, Utzinger, Jürg, Gerber, Markus, Lang, Christin
• Format: Article
• Language: English
• Subjects: Accelerometers; Anemia; Anthropometry; Biology and Life Sciences; Blood pressure; Capillary pressure; Cardiovascular diseases; Care and treatment; Children; Data collection; Diabetes; Diagnosis; Elementary school students; Epidemiology; Exercise; Glucose metabolism; Grip strength; Haemoglobin; Health aspects; Health risks; Heart diseases; Helminthiasis; Hemoglobin; Hypertension; Hypotheses; Infections; Informed consent; Insulin resistance; Intestine; Lipids; Medicine and Health Sciences; Metabolism; Oxygen consumption; Parasites; Participation; Physical activity; Physical fitness; Risk; Risk factors; Schools; Tropical diseases
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0011664

Background/Aim School-aged children in low- and middle-income countries carry the highest burden of intestinal helminth infections, such as soil-transmitted helminths (STH). STH infections have been associated with negative consequences for child physical and cognitive development and wellbeing. With the epidemiological transition and rise in cardiovascular disease (CVD), studies have shown that helminth infections may influence glucose metabolism by preventing obesity. Thus, the aim of this study was to determine the association of STH infections in schoolchildren from Gqeberha, focusing on physical activity, physical fitness, and clustered CVD risk score. Methods This cross-sectional study involved 680 schoolchildren (356 girls and 324 boys; mean age 8.19 years, SD±1.4) from disadvantaged communities in Gqeberha (formerly, Port Elizabeth), South Africa. Stool samples were collected and examined for STH infections using the Kato-Katz method. Physical activity (accelerometer) and physical fitness (grip strength, 20 m shuttle run) were measured using standard procedures. Furthermore, anthropometry, blood pressure, as well as glycated haemoglobin and lipid profile from capillary blood samples were assessed. We employed one-way ANOVAs to identify the associations of STH infections in terms of species and infection intensity with physical activity, physical fitness, and clustered CVD risk score. Results We found a low STH infection prevalence (7.2%) in our study, with participants infected with at least one intestinal helminth species. In comparison to their non-infected peers, children infected with STH had lower mean grip strength scores, but higher mean VO.sub.2 max estimation and higher levels of MVPA (p < .001). When considering type and intensity of infection, a positive association of A. lumbricoides infection and MVPA was found. In contrast, light T. trichiura-infected children had significantly lower grip strength scores compared to non and heavily-infected children. VO.sub.2 max and MVPA were positively associated with light T. trichiura infection. No significant association between the clustered CVD risk score and infection with any STH species was evident. Conclusions STH-infected children had lower grip strength scores than their non-infected peers, yet, achieved higher VO.sub.2 max and MVPA scores. Our study highlights that the type and intensity of STH infection is relevant in understanding the disease burden of STH infections on children's heal