Loading…

Molecular subtypes of Adenovirus-associated acute respiratory infection outbreak in children in Northern Vietnam and risk factors of more severe cases

Background Under the pressure of Human Adenovirus (HAdV)-associated acute respiratory infection (ARI) outbreak in children in Northern Vietnam in the end of 2022, this study was initiated to identify the HAdV subtype(s) and examine the associated clinical features and risk factors of more severe cas...

Full description

Saved in:
Bibliographic Details
Published in:PLoS neglected tropical diseases 2023-11, Vol.17 (11), p.e0011311-e0011311
Main Authors: Nguyen, Dinh-Dung, Phung, Lan Tuyet, Thanh Tran, Huyen Thi, Ly, Ha Thi Thanh, Vo, Anh Hang Mai, Dinh, Nhung Phuong, Doan, Phuong Mai, Nguyen, Anh Thi, Dang, Luc Danh, Doan, Thia Thi, Pham, Khuong Thi, Pham, Huong Lan, Hoang, Dai Xuan, Pham, Thao Ngoc, Tran, Bao Thai, Tran, Trang Thi Thuc, Le, Huong Thi Minh, Pham, An Nhat, Antoniou, Antony, Ho, Nhan Thi
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Under the pressure of Human Adenovirus (HAdV)-associated acute respiratory infection (ARI) outbreak in children in Northern Vietnam in the end of 2022, this study was initiated to identify the HAdV subtype(s) and examine the associated clinical features and risk factors of more severe cases. Methods This study evaluated pediatric patients with ARI which had tested positive for HAdV between October and November 2022 using a multiplex real-time PCR panel. Nasopharyngeal aspirates or nasal swab samples were used for sequencing to identify HAdV subtypes. Clinical data were collected retrospectively. Results Among 97 successfully sequenced samples, the predominant subtypes were HAdV-B3 (83%), HAdV-B7 (16%) and HAdV-C2 (1%). Lower respiratory manifestations were found in 25% of the patients of which 5% were diagnosed with severe pneumonia. There was no significant association between HAdV subtype and clinical features except higher white blood cell and neutrophil counts in those detected with HAdV-B3 (p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0011311