Non-invasive monitoring of neoadjuvant radiation therapy response in soft tissue sarcomas by multiparametric MRI and quantification of circulating tumor DNA—A study protocol

Wide resection remains the cornerstone of localized soft-tissue sarcomas (STS) treatment. Neoadjuvant radiation therapy (NRT) may decrease the risk of local recurrences; however, its effectiveness for different histological STS subtypes has not been systematically investigated. The proposed prospect...

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Published in:PloS one 2023-11, Vol.18 (11), p.e0285580-e0285580
Main Authors: Runkel, Alexander, Braig, David, Bogner, Balazs, Schmid, Adrian, Lausch, Ute, Boneberg, Anika, Brugger, Zacharias, Eisenhardt, Anja, Kiefer, Jurij, Pauli, Thomas, Boerries, Melanie, Fuellgraf, Hannah, Kurowski, Konrad, Bronsert, Peter, Scholber, Jutta, Grosu, Anca-Ligia, Rovedo, Philipp, Bamberg, Fabian, Eisenhardt, Steffen Ulrich, Jung, Matthias
Format: Article
Language:English
Subjects:
Adjuvant treatment
Biobanks
Biomarkers
Biopsy
Biotechnology industry
Breakpoints
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Circulation
Deoxyribonucleic acid
Diagnosis
DNA
Ethylenediaminetetraacetic acid
Gene mutations
Genetic research
Histopathology
Immunohistochemistry
Magnetic resonance
Magnetic resonance imaging
Medical imaging
Medical imaging equipment
Medical research
Medicine and Health Sciences
Medicine, Experimental
Metastasis
Morphology
Next-generation sequencing
Patients
Radiation
Radiation therapy
Radiotherapy
Research and Analysis Methods
Sarcoma
Soft tissues
Study Protocol
Surgery
Surgical outcomes
Tumors
Whole genome sequencing
Wound healing
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Summary:Wide resection remains the cornerstone of localized soft-tissue sarcomas (STS) treatment. Neoadjuvant radiation therapy (NRT) may decrease the risk of local recurrences; however, its effectiveness for different histological STS subtypes has not been systematically investigated. The proposed prospective study evaluates the NRT response in STS using liquid biopsies and the correlation of multiparametric magnetic resonance imaging (mpMRI) with histopathology and immunohistochemistry. Liquid biopsies Preliminary data support the notion that quantification of ctDNA in combination with tumor mass characterization through co-registration of mpMRI and histopathology can predict NRT response of STS. The methods presented in this prospective study are necessary to assess therapy response in heterogeneous tumors and lay the foundation of future patient- and tumor-specific therapy concepts. These methods can be applied to various tumor entities. Thus, the participation and support of a wider group of oncologic surgeons are needed to validate these findings on a larger patient cohort.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0285580