Leader cells mechanically respond to aligned collagen architecture to direct collective migration

Leader cells direct collective migration through sensing cues in their microenvironment to determine migration direction. The mechanism by which leader cells sense the mechanical cue of organized matrix architecture culminating in a mechanical response is not well defined. In this study, we investig...

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Published in:PloS one 2024-01, Vol.19 (1), p.e0296153-e0296153
Main Authors: Lichtenberg, Jessanne Y, Ramamurthy, Ella, Young, Anna D, Redman, Trey P, Leonard, Corinne E, Das, Swadesh K, Fisher, Paul B, Lemmon, Christopher A, Hwang, Priscilla Y
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Breast cancer
Carcinogenesis
Carcinogens
Care and treatment
Cell adhesion & migration
Cell migration
Cell Movement
Collagen
Collagen - pharmacology
Development and progression
Diagnosis
Extracellular matrix
Fibers
Gene expression
Health aspects
Hydrogels
Integrins
Mechanical analysis
Mechanical stimuli
Medicine and Health Sciences
Metastases
Metastasis
Microenvironments
Phenotypes
Physical Sciences
Research and Analysis Methods
Traction force
Tumors
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description Leader cells direct collective migration through sensing cues in their microenvironment to determine migration direction. The mechanism by which leader cells sense the mechanical cue of organized matrix architecture culminating in a mechanical response is not well defined. In this study, we investigated the effect of organized collagen matrix fibers on leader cell mechanics and demonstrate that leader cells protrude along aligned fibers resulting in an elongated phenotype of the entire cluster. Further, leader cells show increased mechanical interactions with their nearby matrix compared to follower cells, as evidenced by increased traction forces, increased and larger focal adhesions, and increased expression of integrin-α2. Together our results demonstrate changes in mechanical matrix cues drives changes in leader cell mechanoresponse that is required for directional collective migration. Our findings provide new insights into two fundamental components of carcinogenesis, namely invasion and metastasis.
doi_str_mv 10.1371/journal.pone.0296153
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subjects Biology and Life Sciences
Breast cancer
Carcinogenesis
Carcinogens
Care and treatment
Cell adhesion & migration
Cell migration
Cell Movement
Collagen
Collagen - pharmacology
Development and progression
Diagnosis
Extracellular matrix
Fibers
Gene expression
Health aspects
Hydrogels
Integrins
Mechanical analysis
Mechanical stimuli
Medicine and Health Sciences
Metastases
Metastasis
Microenvironments
Phenotypes
Physical Sciences
Research and Analysis Methods
Traction force
Tumors
title Leader cells mechanically respond to aligned collagen architecture to direct collective migration
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