Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark

Alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. We investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD. Using a large cohort data o...

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Bibliographic Details
Published in:PloS one 2024-01, Vol.19 (1), p.e0296434-e0296434
Main Authors: Orimoloye, Helen T, He, Di, Li, Tong, Janzen, Carla, Barjaktarevic, Igor, Wang, Xuexia, Hansen, Johnni, Heck, Julia E
Format: Article
Language:English
Subjects:
Abdomen
alpha 1-Antitrypsin
Alpha 1-antitrypsin deficiency
alpha 1-Antitrypsin Deficiency - complications
alpha 1-Antitrypsin Deficiency - diagnosis
alpha 1-Antitrypsin Deficiency - epidemiology
Biology and Life Sciences
Birth weight
Care and treatment
Child
Childbirth
Children
Children & youth
Chronic obstructive pulmonary disease
Codes
Cohort analysis
Cohort Studies
Complications and side effects
Confidence intervals
Congenital diseases
Denmark - epidemiology
Development and progression
Diagnosis
Female
Gene mutations
Genetic aspects
Gestational age
Health aspects
Humans
Infant, Newborn
Liver
Liver cirrhosis
Liver diseases
Low birth weight
Lung diseases
Maternal & child health
Medicine and Health Sciences
Mothers
Neonatology
Patient outcomes
Placenta
Pneumothorax
Population studies
Pre-eclampsia
Preeclampsia
Pregnancy
Pregnancy complications
Pregnancy Complications - epidemiology
Pregnancy, Complications of
Pregnant women
Premature Birth
Proteins
Risk
Smoking
Statistical analysis
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Summary:Alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. We investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD. Using a large cohort data of Danish mothers and children with AATD from 1973 to 2013 (n = 2,027,229), with 559 cases (305 mothers and 254 children). We conducted Poisson regression to examine associations between alpha-1 antitrypsin deficiency, adverse birth outcomes, and pregnancy complications in mothers and children. AATD was related to term low birth weight [
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0296434