Antimicrobial resistance patterns of WHO priority pathogens isolated in hospitalized patients in Japan: A tertiary center observational study

• Published in: PloS one 2024-01, Vol.19 (1), p.e0294229-e0294229
• Main Authors: Nisa, Tania Tabassum, Nakatani, Daisaku, Kaneko, Fumie, Takeda, Toshihiro, Nakata, Ken
• Format: Article
• Language: English
• Subjects: Ampicillin; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Binomial distribution; Biology and Life Sciences; Carbapenems; Care and treatment; Cephalosporins; Chronic illnesses; Complications and side effects; Diabetes; Diabetes mellitus; Drug resistance; Drug resistance in microorganisms; E coli; Epidemiology; Health surveillance; Hospitalization; Hospitals; Kidney diseases; Klebsiella; Medical records; Medicine and Health Sciences; Methicillin; Mortality; Observational studies; Organisms; Pathogens; Patient outcomes; Patients; Penicillin; Phases; Public health; R&D; Research & development; Review boards; Subgroups; Vancomycin
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0294229

After issuing the "Global action plan on antimicrobial resistance" in 2015, the World Health Organization (WHO) established a priority pathogens list for supporting research and development of novel antimicrobials. We conducted a comprehensive analysis of the WHO priority organisms in a Japanese tertiary hospital to apprehend the local AMR epidemiology. Data were obtained from electrical medical records in Osaka University Hospital between January 2010 and March 2021. The critical, high, and medium "priority pathogens list" categories of the WHO were used to compare results between the early (2010-2015) and late (2016-2021) phases. Out of 52,130 culture-positive specimens, a total of 9,872 (18.9%) contained WHO priority isolates. In comparison to early phases, late phases were likely to have higher rates of carbapenem resistance in Pseudomonas aeruginosa (15.7% vs 25.0%, P