The effect of oral chronic graft-versus-host disease on bodyweight: A cohort study

This retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease). Patients with oral cGVHD were compared with an age and gender-matched non-GVHD cohort in terms of demographic information, body mass index (BMI), date of transpla...

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Bibliographic Details
Published in:PloS one 2024-01, Vol.19 (1), p.e0293873-e0293873
Main Authors: Aboalela, Ali Anwar, Farook, Fathima Fazrina, Alazaz, Norah N, Alshahrani, Nada, Alharthi, Aalia, Hagr, Roa
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Body mass index
Body size
Body weight
Care and treatment
Clinical significance
Comparative analysis
Complications and side effects
Diagnosis
Dysphagia
Erythema
Exocrine glands
Graft versus host disease
Graft versus host reaction
Health aspects
Hematopoietic stem cells
Infections
Malnutrition
Medical research
Medical treatment
Medicine and Health Sciences
Medicine, Experimental
Mouth
Mucositis
Pain
Patients
Stem cells
Transplantation
Transplants & implants
Underweight
Weight loss
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Summary:This retrospective cohort study aimed to evaluate the association between body weight and oral cGVHD (chronic graft versus host disease). Patients with oral cGVHD were compared with an age and gender-matched non-GVHD cohort in terms of demographic information, body mass index (BMI), date of transplant, length of hospitalization, and oral complications. Weight was stratified in pre-and post-transplant weight, mean weight after acquiring cGVHD for the first year, and post-oral cGVHD BMI. Each patient was matched and compared with two controls at a 1:2 ratio. Firth's penalized likelihood logistic regression was used to investigate the association between oral complications and weight loss greater than 5% in the oral cGVHD group. This study included 137 patients (n = 42 oral cGVHD, n = 12 non oral-cGVHD and n = 83 non-GVHD). The oral cGVHD cohort had a 1.44 times higher risk (RR) of being underweight (BMI
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0293873